spermine [Ligand Id: 710] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL23194 (4,9-diazadodecamethylenediamine, Actilip sp-91, Gerotine, Musculamine, Neuridine, NSC-268508, Spermine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method | B | 4.13 | pKi | 74000 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 4.08 | pKi | 84000 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.08 | pKi | 84000 | nM | Ki | Bioorg Med Chem (2011) 19: 1381-1389 [PMID:21282059] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method | B | 4.88 | pKi | 13300 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| ChEMBL | Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.88 | pKi | 13300 | nM | Ki | Bioorg Med Chem (2011) 19: 1381-1389 [PMID:21282059] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method | B | 6.08 | pKi | 840 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method | B | 6.08 | pKi | 830 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method | B | 6 | pKi | 990 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method | B | 6.15 | pKi | 710 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method | B | 4.56 | pKi | 27600 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| ChEMBL | Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.56 | pKi | 27600 | nM | Ki | Bioorg Med Chem (2011) 19: 1381-1389 [PMID:21282059] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method | B | 4.65 | pKi | 22600 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method | B | 6.07 | pKi | 860 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Caspase 2/Caspase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4884] [GtoPdb: 1618] [UniProtKB: P42575] | ||||||||
| ChEMBL | Activation of procaspase 2 after 24 hrs | B | 5.07 | pEC50 | 8500 | nM | EC50 | J Med Chem (2008) 51: 2346-2349 [PMID:18366176] |
| GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
| ChEMBL | Ability to enhance [3H]MK-801 binding to NMDA receptors in rat forebrain membranes was calculated with respect to spermine | B | 5.28 | pEC50 | 5200 | nM | EC50 | J Med Chem (1995) 38: 4891-4896 [PMID:8523402] |
| GluN1/GluN2B/Glutamate NMDA receptor; Grin1/Grin2b in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096666] [GtoPdb: 455, 457] [UniProtKB: P35439, Q00960] | ||||||||
| ChEMBL | Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glycine-induced current response by whole cell voltage clamp method | B | 4 | pEC50 | 100000 | nM | EC50 | J Med Chem (2017) 60: 5556-5585 [PMID:28586221] |
| GluN2B/Glutamate [NMDA] receptor subunit epsilon 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL311] [GtoPdb: 457] [UniProtKB: Q00960] | ||||||||
| ChEMBL | Positive allosteric modulation of GluN2B receptor in rat spinal cord neurons assessed as increase in glycine-induced channel current by two electrode voltage clamp method | B | 4.09 | pEC50 | 81000 | nM | EC50 | J Med Chem (2018) 62: 3-23 [PMID:29446949] |
| CaS receptor in Human [GtoPdb: 54] [UniProtKB: P41180] | ||||||||
| GtoPdb | - | - | 3.5 | pKd | - | - | - | Am J Physiol (1997) 273: C1315-23 [PMID:9357776] |
| Kir2.1 in Mouse [GtoPdb: 430] [UniProtKB: P35561] | ||||||||
| GtoPdb | - | - | 9.1 | pKd | - | - | - |
Neuron (1995) 14: 1047-54 [PMID:7748552]; J Physiol (Lond.) (1996) 491 ( Pt 2): 367-81 [PMID:8866861] |
| TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 61000 | nM | IC50 | Pflugers Arch (2004) 448: 70-5 [PMID:14758478] |
| TRPM4 in Mouse [GtoPdb: 496] [UniProtKB: Q7TN37] | ||||||||
| GtoPdb | - | - | 4.5 | pIC50 | - | - | - | Cell Calcium (2005) 37: 267-78 [PMID:15670874] |
| TRPM5 in Human [GtoPdb: 497] [UniProtKB: Q9NZQ8] | ||||||||
| GtoPdb | - | - | 4.43 | pIC50 | 37000 | nM | IC50 | |
| TRPM7 in Rat [GtoPdb: 499] [UniProtKB: Q925B3] | ||||||||
| GtoPdb | - | - | 5.64 | pKi | 2300 | nM | Ki | J Gen Physiol (2002) 120: 221-35 [PMID:12149283] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
