MPDT [Ligand Id: 71] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL7318
  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • This target only has 1 pki data point
  • 5
1 CHEMBL7318_lig_chart_1 Norepinephrine transporter Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5.82
2 CHEMBL7318_lig_chart_2 Serotonin 1a (5-HT1a) receptor Human
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
  • 5.2
3 CHEMBL7318_lig_chart_3 Serotonin 1d (5-HT1d) receptor Human
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  • 5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
  • This target only has 1 pki data point
  • 5
4 CHEMBL7318_lig_chart_4 Serotonin 1e (5-HT1e) receptor Human
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
  • 6.31
5 CHEMBL7318_lig_chart_5 Serotonin 2a (5-HT2a) receptor Rat
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
  • 6.19
6 CHEMBL7318_lig_chart_6 Serotonin 2c (5-HT2c) receptor Rat
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  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
  • 5.29
7 CHEMBL7318_lig_chart_7 Serotonin 5a (5-HT5a) receptor Human
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • 7.7
8 CHEMBL7318_lig_chart_8 Serotonin 6 (5-HT6) receptor Human
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • 6.8
9 CHEMBL7318_lig_chart_9 Serotonin 7 (5-HT7) receptor Human
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 1 pki data point
  • 5.33
10 CHEMBL7318_lig_chart_10 Serotonin transporter Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Compound was evaluated for its binding affinity towards human NET(norepinephrine) transporter B 5 pKi >10000 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 5.8 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1A receptor B 5.83 pKi 1470 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 5.2 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor B 5.21 pKi 6225 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor B 5 pKi >10000 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
GtoPdb - - 6.3 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
ChEMBL Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2A receptor B 6.33 pKi 470 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2C receptor B 6.17 pKi 675 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
GtoPdb - - 6.2 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 5A receptor B 5.29 pKi 5160 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
GtoPdb - - 5.3 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Binding affinity for human 5-hydroxytryptamine 6 receptor expressed in HEK 293 human embryonic kidney cells, [3H]-lysergic acid diethylamide as radioligand B 7.27 pKi 54 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
ChEMBL Binding affinity for human 5-hydroxytryptamine 6 receptor B 7.3 pKi 50.12 nM Ki J. Med. Chem. (2005) 48: 4216-4219 [PMID:15974573]
ChEMBL Binding affinity towards human 5-hydroxytryptamine 6 receptor B 7.7 pKi 20 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL Binding affinity to 5-HT6 receptor (unknown origin) B 7.7 pKi 20 nM Ki Med Chem Res (2005) 14: 1-18
ChEMBL Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectrometry B 7.7 pKi 20 nM Ki J. Med. Chem. (2015) 58: 7901-7912 [PMID:26099069]
ChEMBL Binding affinity against 5 Hydroxy tryptamine 6 receptor B 7.7 pKi 20 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 1707-1711 [PMID:15745826]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 6 receptor B 7.7 pKi 20 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
GtoPdb - - 7.7 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
GtoPdb - - 6.8 pKi - - - J Med Chem (2000) 43: 1011-8 [PMID:10715164]
ChEMBL Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor B 6.81 pKi 155 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Compound was evaluated for its binding affinity towards human serotonin transporter B 5.33 pKi 4700 nM Ki J. Med. Chem. (2000) 43: 1011-1018 [PMID:10715164]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]