ChEMBL ligand: CHEMBL1200934 (Dexnorgestrel acetime, Norgestimate, Norgestimate component of ortho tri-cyclen, Norgestimate component of prefest, Norgestimate component of previfem, Norgestimate component of sprintec, Norgestimate component of tri lo sprintec, Norgestimate component of tri-previfem, Norgestimate component of tri-sprintec, Norgestimato, NSC-759159, ORF 10131, ORF-10131, RWJ 10131, RWJ-10131)
TRPC3 in Human [GtoPdb: 488] [UniProtKB: Q13507] There should be some charts here, you may need to enable JavaScript!
TRPC6 in Human [GtoPdb: 491] [UniProtKB: Q9Y210] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
TRPC3 in Human [GtoPdb: 488] [UniProtKB: Q13507]
GtoPdb	Norgestimate-induced inhibition of hTRPC3-mediated Ca2+ entry in transfected CHO cells stimulated with the OAG diacylglycerol analog.	-	5.52	pKi	3000	nM	Ki	PLoS ONE (2012) 7: e35393 [PMID:22530015]
TRPC6 in Human [GtoPdb: 491] [UniProtKB: Q9Y210]
GtoPdb	Norgestimate-induced inhibition of hTRPC6-mediated Ca2+ entry in transfected HEK-FITR cells stimulated with the OAG diacylglycerol analog.	-	5.28	pIC50	5200	nM	IC50	PLoS ONE (2012) 7: e35393 [PMID:22530015]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]