teduglutide [Ligand Id: 7049] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2104987 (ALX 0600, ALX-0600, Gattex, Gattex kit, Revestive, Teduglutide, Teduglutide (rdna origin)) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GLP-1 receptor/Glucagon-like peptide 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1784] [GtoPdb: 249] [UniProtKB: P43220] | ||||||||
| ChEMBL | Agonist activity at human GLP1R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay | B | 6 | pEC50 | >1000 | nM | EC50 | J Med Chem (2016) 59: 3129-3139 [PMID:26986178] |
| GLP-2 receptor/Glucagon-like peptide 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5844] [GtoPdb: 250] [UniProtKB: O95838] | ||||||||
| ChEMBL | Agonist activity at human GLP2R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay | B | 10.05 | pEC50 | 0.09 | nM | EC50 | J Med Chem (2016) 59: 3129-3139 [PMID:26986178] |
| ChEMBL | Agonist activity at human GLP2 receptor expressed in HEK293 cells assessed as increase in intracellular cAMP accumulation by AlphaScreen assay | F | 11 | pEC50 | 0.01 | nM | EC50 | US-20160355563-A1. Glucagon-like-peptide-2 (glp-2) analogues (2016) |
| GLP-2 receptor/Glucagon-like peptide 2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3822349] [GtoPdb: 250] [UniProtKB: Q9Z0W0] | ||||||||
| ChEMBL | Agonist activity at rat GLP2R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay | B | 10.1 | pEC50 | 0.08 | nM | EC50 | J Med Chem (2016) 59: 3129-3139 [PMID:26986178] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
