indisulam [Ligand Id: 7046] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL77517 (E-7070, E7070, Indisulam) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] | ||||||||
| ChEMBL | Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.65 | pKi | 226 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] | ||||||||
| ChEMBL | Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay | B | 6.79 | pKi | 163 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay | B | 6.79 | pKi | 163 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] | ||||||||
| ChEMBL | Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 6.37 | pKi | 423 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] | ||||||||
| ChEMBL | Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 7.08 | pKi | 84.1 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] | ||||||||
| ChEMBL | Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay | B | 6.14 | pKi | 717 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] | ||||||||
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 6.4 | pKi | 394 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] | ||||||||
| ChEMBL | Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay | B | 5.96 | pKi | 1090 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 5.96 | pKi | 1090 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] | ||||||||
| ChEMBL | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | B | 7.03 | pKi | 94 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020] |
| Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay | B | 6.88 | pKi | 133 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] | ||||||||
| ChEMBL | Inhibition of Helicobacter pylori recombinant CA | B | 6.36 | pKi | 434 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay | B | 6.38 | pKi | 413 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] | ||||||||
| ChEMBL | Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 6.02 | pKi | 963 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] | ||||||||
| ChEMBL | Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 6.56 | pKi | 273 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay | B | 7.01 | pKi | 97 | nM | Ki | J Med Chem (2009) 52: 4063-4067 [PMID:19438226] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase I | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2005) 48: 2121-2125 [PMID:15771455] |
| ChEMBL | Inhibitory activity against cytosolic human carbonic anhydrase I | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21 | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Binding affinity towards human cloned carbonic anhydrase I | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase I | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091] |
| ChEMBL | Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration method | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2005) 48: 4834-4841 [PMID:16033263] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase I | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325] |
| ChEMBL | Inhibition constant against human carbonic anhydrase I | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204] |
| ChEMBL | Inhibitory activity against human cloned Carbonic anhydrase I by the CO2 hydration method | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA1 | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| ChEMBL | Inhibition of human cloned CA1 by CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036] |
| ChEMBL | Inhibition of human cloned CA1 by CO2 hydration method | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2006) 49: 6539-6548 [PMID:17064072] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human recombinant isozyme CA1 by CO2 hydration method | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2007) 50: 1651-1657 [PMID:17343373] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722] |
| ChEMBL | Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human CA1 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Eur J Med Chem (2014) 71: 135-147 [PMID:24291567] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human cloned cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Eur J Med Chem (2014) 82: 47-55 [PMID:24871996] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 using p-nitrophenyl acetate as substrate by esterase assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1337-1341 [PMID:26804228] |
| ChEMBL | Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| GtoPdb | - | - | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Inhibition constant evaluated for the inhibition of human CA I (Carbonic anhydrase I) | B | 7.52 | pKi | 30 | nM | Ki | J Med Chem (2004) 47: 2337-2347 [PMID:15084132] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I | B | 7.52 | pKi | 30 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984] |
| ChEMBL | Inhibitory activity of compound against human carbonic anhydrase I | F | 7.51 | pIC50 | 31 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay | B | 5.11 | pKi | 7840 | nM | Ki | J Med Chem (2009) 52: 4063-4067 [PMID:19438226] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039] |
| ChEMBL | Inhibition constant evaluated for the inhibition of human CA II (Carbonic anhydrase II) | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2004) 47: 2337-2347 [PMID:15084132] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2005) 48: 2121-2125 [PMID:15771455] |
| ChEMBL | Inhibitory activity against cytosolic human carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21 | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Binding affinity towards human cloned carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091] |
| ChEMBL | Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2005) 48: 4834-4841 [PMID:16033263] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325] |
| ChEMBL | Inhibition constant against human carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204] |
| ChEMBL | Inhibitory activity against human cloned Carbonic anhydrase II by the CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351] |
| ChEMBL | Inhibition of cloned human carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2005) 48: 5721-5727 [PMID:16134940] |
| ChEMBL | Inhibitory activity against human recombinant cytosolic CA2 | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA2 | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| ChEMBL | Inhibition of human cloned CA2 by CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036] |
| ChEMBL | Inhibition of human cloned CA2 by CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2006) 49: 6539-6548 [PMID:17064072] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human recombinant isozyme CA2 by CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2007) 50: 1651-1657 [PMID:17343373] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722] |
| ChEMBL | Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| ChEMBL | Inhibition of human CA2 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Eur J Med Chem (2014) 71: 135-147 [PMID:24291567] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Eur J Med Chem (2014) 82: 47-55 [PMID:24871996] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556] |
| ChEMBL | Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 using p-nitrophenyl acetate as substrate by esterase assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1337-1341 [PMID:26804228] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of full length human CA 2 | B | 7.82 | pKi | 15 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibitory activity of compound against human carbonic anhydrase II | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154] |
| Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kinetic assay | B | 4.98 | pKi | 10400 | nM | Ki | Bioorg Med Chem (2007) 15: 7229-7236 [PMID:17826101] |
| Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323] | ||||||||
| ChEMBL | Inhibitory activity against carbonic anhydrase IV from bovine lung microsomes | B | 7.19 | pKi | 65 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984] |
| ChEMBL | Inhibition constant evaluated for the inhibition of bovine CA IV (Carbonic anhydrase IV) | B | 7.19 | pKi | 65 | nM | Ki | J Med Chem (2004) 47: 2337-2347 [PMID:15084132] |
| ChEMBL | Inhibitory activity of compound against bovine carbonic anhydrase IV | F | 7.19 | pIC50 | 65 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039] |
| ChEMBL | Inhibition constant evaluated for the inhibition of human CA IX (Carbonic anhydrase IX) | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2004) 47: 2337-2347 [PMID:15084132] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2005) 48: 2121-2125 [PMID:15771455] |
| ChEMBL | Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21 | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Binding affinity towards human cloned carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091] |
| ChEMBL | Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2005) 48: 4834-4841 [PMID:16033263] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325] |
| ChEMBL | Inhibition constant against human carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204] |
| ChEMBL | Inhibitory activity against catalytic domain of human cloned Carbonic anhydrase IX by the CO2 hydration method | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351] |
| ChEMBL | Inhibition of catalytic domain of human recombinant carbonic anhydrase IX | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2005) 48: 5721-5727 [PMID:16134940] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| ChEMBL | Inhibition of human cloned CA9 catalytic domain by CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036] |
| ChEMBL | Inhibition of human cloned CA9 catalytic domain by CO2 hydration method | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2006) 49: 6539-6548 [PMID:17064072] |
| ChEMBL | Inhibition of catalytic domain of human recombinant CA IX | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2007) 50: 1651-1657 [PMID:17343373] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072] |
| ChEMBL | Inhibition of human CA9 | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2008) 51: 1945-1953 [PMID:18307288] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human carbonic anhydrase 9 | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722] |
| ChEMBL | Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Eur J Med Chem (2014) 71: 135-147 [PMID:24291567] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Eur J Med Chem (2014) 82: 47-55 [PMID:24871996] |
| ChEMBL | Inhibition of human CA 9 catalytic domain | B | 7.62 | pKi | 24 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Eur J Med Chem (2021) 217: 113351-113351 [PMID:33744685] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VA | B | 7.1 | pKi | 79 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VB | B | 7.64 | pKi | 23 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of full length human recombinant CA VI | B | 7.33 | pKi | 47 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay | B | 7.33 | pKi | 47 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay | B | 7.33 | pKi | 47 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| GtoPdb | - | - | 6.91 | pKi | 122 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.91 | pKi | 122 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 6.91 | pKi | 122 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition constant against human carbonic anhydrase XII | B | 8.47 | pKi | 3.4 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204] |
| ChEMBL | Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722] |
| ChEMBL | Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Eur J Med Chem (2014) 71: 135-147 [PMID:24291567] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Eur J Med Chem (2014) 82: 47-55 [PMID:24871996] |
| ChEMBL | Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.47 | pKi | 3.4 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 2377-2381 [PMID:25913118] |
| GtoPdb | - | - | 8.47 | pKi | 3.4 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Inhibition of human CA 12 catalytic domain | B | 8.52 | pKi | 3 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.98 | pKi | 104 | nM | Ki | Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722] |
| ChEMBL | Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.98 | pKi | 104 | nM | Ki | Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216] |
| Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] | ||||||||
| ChEMBL | Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.43 | pKi | 375 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by by stopped flow CO2 hydration assay | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2009) 52: 4063-4067 [PMID:19438226] |
| Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay | B | 7.01 | pKi | 97 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by by stopped flow CO2 hydration assay | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2009) 52: 4063-4067 [PMID:19438226] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
