apabetalone [Ligand Id: 7034] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2393130 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| bromodomain containing 2 in Human [GtoPdb: 1944] [UniProtKB: P25440] | ||||||||
| GtoPdb | Measured using a TR-FRET assay to evaluate binding to BD2 of BRD2. | - | 7.05 | pIC50 | 90 | nM | IC50 | PLoS ONE (2013) 8: e83190 [PMID:24391744] |
| bromodomain containing 4 in Human [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
| GtoPdb | Measured using a TR-FRET assay to evaluate binding to BD2 of BRD4. | - | 7.4 | pIC50 | 40 | nM | IC50 | PLoS ONE (2013) 8: e83190 [PMID:24391744] |
| bromodomain containing 3 in Human [GtoPdb: 2725] [UniProtKB: Q15059] | ||||||||
| GtoPdb | AlphaScreen data for bromodomain 1 of BRD3. | - | 4.06 | pIC50 | 87000 | nM | IC50 | Proc Natl Acad Sci USA (2013) 110: 19754-9 [PMID:24248379] |
| GtoPdb | AlphaScreen data assessing the bromodomain 2 domain of BRD3. | - | 5.31 | pIC50 | 4900 | nM | IC50 | Proc Natl Acad Sci USA (2013) 110: 19754-9 [PMID:24248379] |
| GtoPdb | Measured using a TR-FRET assay to evaluate binding to BD2 of BRD3. | - | 6.55 | pIC50 | 280 | nM | IC50 | PLoS ONE (2013) 8: e83190 [PMID:24391744] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
