ChEMBL ligand: CHEMBL27759 (Entinostat, MS-27-275, MS-275, MS-275-27, SNDX-275)
bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] There should be some charts here, you may need to enable JavaScript!
coagulation factor III, tissue factor/Coagulation factor III in Human [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Histone deacetylase in Plasmodium falciparum [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 11/Histone deacetylase 11 in Human [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 5/Histone deacetylase 5 in Human [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 7/Histone deacetylase 7 in Human [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] There should be some charts here, you may need to enable JavaScript!
Histone deacetylase 8 in Schistosoma mansoni [ChEMBL: CHEMBL3797017] [UniProtKB: A5H660] histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 9/Histone deacetylase 9 in Human [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] There should be some charts here, you may need to enable JavaScript!
Histone deacetylase-like amidohydrolase in Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) [ChEMBL: CHEMBL6017] [UniProtKB: Q70I53] There should be some charts here, you may need to enable JavaScript!
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] There should be some charts here, you may need to enable JavaScript!
sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
ChEMBL	Inhibition of His-tagged BRD4 bromodomain 1 (unknown origin) using [Lys (5,8,12,16) Ac] H4(1-21) as substrate by fluorescence based assay	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2021) 209: 112868-112868 [PMID:33077265]
ChEMBL	Inhibition of His-tagged BRD4 bromodomain 2 (unknown origin) using [Lys (5,8,12,16) Ac] H4(1-21) as substrate by fluorescence based assay	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2021) 209: 112868-112868 [PMID:33077265]
coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726]
ChEMBL	Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay	B	5	pIC50	10000	nM	IC50	J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
ChEMBL	Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay	B	5.22	pIC50	6000	nM	IC50	J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG by automated patch clamp assay	B	4.52	pIC50	>30000	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 4909-4912 [PMID:21742496]
ChEMBL	Inhibition of human ERG by automated Q-patch assay	B	4.52	pIC50	>30000	nM	IC50	J. Med. Chem. (2011) 54: 4752-4772 [PMID:21650221]
Histone deacetylase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7]
ChEMBL	Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells	B	6.03	pIC50	940	nM	IC50	J. Med. Chem. (2009) 52: 2185-2187 [PMID:19317450]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL	Inhibition of human HDAC1	B	7.66	pKi	22	nM	Ki	Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
GtoPdb	-	-	7.66	pKi	22	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	HDAC enzyme inhibitionAssay: HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48 and Perez-Balado et al., 2007, J. Med. Chem., 50:2497-2505. Inhibition assays using nuclear extract were performed essentially as described in Herman et al., 2006, Nat. Chem. Biol., 2:551-558. Briefly, the purified HDACs or nuclear extract were incubated with an acetylated substrate in the absence of the compound to be assayed and with increasing concentrations of the compound. The rate of substrate deacetylation was measured under each condition, and half-maximal inhibitory concentration with regard to each HDAC was determined by standard means.	B	5.49	pIC50	3200	nM	IC50	US-9265734-B2. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors (2016)
ChEMBL	Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)	B	5.7	pIC50	2000	nM	IC50	J. Med. Chem. (2003) 46: 820-830 [PMID:12593661]
ChEMBL	Inhibition of KDAC1 in human K562 cells using [3H]acetylated histone as substrate incubated for 10 mins by liquid scintillation counting method	B	5.83	pIC50	1480	nM	IC50	J. Med. Chem. (2016) 59: 1613-1633 [PMID:26681404]
ChEMBL	Inhibition of human FLAG-tagged HDAC1 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection based assay	B	5.97	pIC50	1070	nM	IC50	Eur J Med Chem (2018) 144: 612-625 [PMID:29289885]
ChEMBL	Ability to inhibit recombinant human histone deacetylase 1 (HDAC-1).	B	6	pIC50	1000	nM	IC50	Bioorg. Med. Chem. Lett. (2004) 14: 283-287 [PMID:14684344]
ChEMBL	Inhibition of human HDAC1	B	6	pIC50	1000	nM	IC50	J. Med. Chem. (2008) 51: 1505-1529 [PMID:18247554]
ChEMBL	Inhibition of HDAC1	B	6.22	pIC50	600	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 110-116 [PMID:21145737]
ChEMBL	Inhibition of human HDAC1 using RHKKAc as substrate by fluorescence assay	B	6.26	pIC50	544	nM	IC50	Eur J Med Chem (2019) 162: 612-630 [PMID:30476825]
ChEMBL	Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluorescence analysis	B	6.26	pIC50	544	nM	IC50	Eur J Med Chem (2020) 196: 112291-112291 [PMID:32325365]
ChEMBL	Inhibition of HDAC1 (unknown origin) using fluorogenic-(RHKKAc) as substrate by fluorescence assay	B	6.26	pIC50	544	nM	IC50	Eur J Med Chem (2021) 215: 113169-113169 [PMID:33588178]
ChEMBL	Inhibition of recombinant human full-length C-terminal FLAG-His tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay	B	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2020) 192: 112158-112158 [PMID:32171161]
ChEMBL	Inhibition of human recombinant HDAC1	B	6.27	pIC50	540	nM	IC50	J. Med. Chem. (2007) 50: 5543-5546 [PMID:17941625]
ChEMBL	Inhibition of recombinant human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate incubated for 90 mins by fluorescence assay	B	6.28	pIC50	519	nM	IC50	J Med Chem (2019) 62: 11260-11279 [PMID:31762274]
ChEMBL	Inhibition of HADC1 (unknown origin)	B	6.29	pIC50	510	nM	IC50	J Med Chem (2020) 63: 23-39 [PMID:31415174]
ChEMBL	Inhibition of HDAC1 using Fluor de Lys as substrate by fluorescence analysis	B	6.3	pIC50	500	nM	IC50	Eur. J. Med. Chem. (2012) 53: 390-397 [PMID:22541394]
ChEMBL	Inhibition of HDAC1	B	6.3	pIC50	500	nM	IC50	Bioorg. Med. Chem. (2010) 18: 3925-3933 [PMID:20452226]
ChEMBL	Inhibition of purified recombinant HDAC1	B	6.31	pIC50	485	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 4909-4912 [PMID:21742496]
ChEMBL	Inhibition of HDAC1	B	6.32	pIC50	480	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 1926-1930 [PMID:22321215]
ChEMBL	Inhibition of HDAC1 (unknown origin) using deacetylase fluorogenic substrate pretreated for 5 mins followed by substrate addition after 30 mins by fluorescence assay	B	6.39	pIC50	410	nM	IC50	Eur J Med Chem (2017) 132: 42-62 [PMID:28340413]
ChEMBL	Inhibition of recombinant HDAC1 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	B	6.41	pIC50	390	nM	IC50	Eur. J. Med. Chem. (2015) 96: 1-13 [PMID:25874326]
ChEMBL	Inhibition of recombinant HDAC1 (unknown origin) incubated for 10 mins using Boc-Lys(acetyl)-AMC fluorogenic substrate by homogeneous fluorescence release assay	B	6.41	pIC50	390	nM	IC50	Bioorg. Med. Chem. (2015) 23: 3457-3471 [PMID:25953722]
ChEMBL	Inhibition of HDAC1	B	6.43	pIC50	368	nM	IC50	Eur. J. Med. Chem. (2012) 53: 390-397 [PMID:22541394]
ChEMBL	Inhibition of human recombinant HDAC1 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by fluorescence assay	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2018) 143: 320-333 [PMID:29202397]
ChEMBL	Inhibition of human recombinant His-tagged HDAC1 (482 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence method	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2019) 173: 185-202 [PMID:31003060]
ChEMBL	Inhibition of human recombinant HDAC1 using p53 residues 379-382 (RHKKAc) as substrate	B	6.51	pIC50	310	nM	IC50	Bioorg. Med. Chem. (2013) 21: 5339-5354 [PMID:23820574]
ChEMBL	Inhibition of human HDAC1 in U937 cells by immunoprecipitation assay	B	6.52	pIC50	300	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 2530-2535 [PMID:18381238]
ChEMBL	Inhibition of HDAC1 by in vitro deacetylation assay	B	6.52	pIC50	300	nM	IC50	Nat. Chem. Biol. (2010) 6: 25-33 [PMID:19966789]
ChEMBL	Inhibition of HDAC1 (unknown origin) after 60 mins by fluorescence assay	B	6.52	pIC50	<300	nM	IC50	J. Med. Chem. (2013) 56: 4816-4820 [PMID:23672185]
ChEMBL	Inhibition of HDAC1 (unknown origin) preincubated for 5 mins followed by fluorogenic substrate addition measured after 30 mins by microplate reader analysis	B	6.56	pIC50	273	nM	IC50	Eur. J. Med. Chem. (2015) 100: 270-276 [PMID:26140961]
ChEMBL	Inhibition of HDAC1 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by fluorescence analysis	B	6.57	pIC50	271	nM	IC50	Bioorg Med Chem (2017) 25: 4123-4132 [PMID:28629630]
ChEMBL	Inhibition of human recombinant C-terminal His/FLAG-tagged HDAC1 using Boc-Lys-(epsilon-Ac)-AMC as fluorogenic substrate incubated for 90 mins by fluorescence based assay	B	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2019) 177: 457-466 [PMID:31181405]
ChEMBL	Inhibition of HDAC1	B	6.74	pIC50	180	nM	IC50	J. Med. Chem. (2008) 51: 1505-1529 [PMID:18247554]
ChEMBL	Inhibition of HDAC1 (unknown origin) by fluorescence based assay	B	6.75	pIC50	178.3	nM	IC50	Eur J Med Chem (2021) 209: 112868-112868 [PMID:33077265]
ChEMBL	Inhibition of HDAC1 (unknown origin) using Boc-Lys (acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition measured after 1 hr by fluorescence assay	B	6.79	pIC50	163	nM	IC50	Bioorg Med Chem (2017) 25: 2981-2994 [PMID:28511906]
ChEMBL	Inhibition of HDAC1 (unknown origin) using fluorogenic substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence-based assay	B	6.8	pIC50	160	nM	IC50	J Med Chem (2018) 61: 5304-5322 [PMID:29787262]
ChEMBL	Inhibition of recombinant HDAC1 (unknown origin) using of Fluor-de-Lys substrate incubated for 10 mins by fluorimetric assay	B	6.85	pIC50	140	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 2931-2935 [PMID:27142751]
ChEMBL	Inhibition of HDAC1	B	6.9	pIC50	125	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 726-731 [PMID:18060775]
ChEMBL	Inhibition of human C-terminal FLAG-tagged HDAC1 in HEK293 cells	B	6.92	pIC50	120	nM	IC50	J. Med. Chem. (2009) 52: 3453-3456 [PMID:19441846]
ChEMBL	Inhibition of HDAC1 by fluorogenic enzyme assay	B	6.92	pIC50	120	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 3651-3656 [PMID:19457659]
ChEMBL	Inhibition of HDAC1	B	6.92	pIC50	120	nM	IC50	J. Med. Chem. (2008) 51: 2350-2353 [PMID:18370373]
ChEMBL	Inhibition of HDAC1 in HEK293 cells	B	6.92	pIC50	120	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay	B	6.93	pIC50	118	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of HDAC1 (mean IC50)	B	6.96	pIC50	110	nM	IC50	Bioorg. Med. Chem. Lett. (2006) 16: 5948-5952 [PMID:16987657]
ChEMBL	Inhibition of HDAC1 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	B	7	pIC50	<100	nM	IC50	Bioorg. Med. Chem. (2012) 20: 4430-4436 [PMID:22705022]
ChEMBL	Inhibition of recombinant human full length HDAC1 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysis	B	7	pIC50	99	nM	IC50	Eur J Med Chem (2017) 134: 13-23 [PMID:28395150]
ChEMBL	Inhibition of recombinant HDAC1 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs by fluorescence based micro plate reader analysis	B	7.27	pIC50	53.89	nM	IC50	J Med Chem (2020) 63: 5501-5525 [PMID:32321249]
ChEMBL	Inhibition of recombinant human HDAC1 using Cbz-Lys(TFAc)-AMC as substrate by fluorometric analysis	B	7.36	pIC50	44	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 7067-7070 [PMID:20947351]
ChEMBL	Inhibition of HDAC1	B	7.6	pIC50	25	nM	IC50	Bioorg. Med. Chem. (2010) 18: 4103-4110 [PMID:20472442]
ChEMBL	Inhibition of recombinant human HDAC1 using pan-HDAC substrate incubated for 3 hrs by fluorescence method	B	9.7	pIC50	0.2	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
ChEMBL	Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assay	B	6	pEC50	1000	nM	EC50	J. Med. Chem. (2008) 51: 1505-1529 [PMID:18247554]
GtoPdb	-	-	6.74	pEC50	181	nM	EC50	Biochem J (2008) 409: 581-9 [PMID:17868033]
ChEMBL	Inhibition of recombinant human N-terminal GST/flag-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells after 3 hrs by fluorescence assay	B	6.74	pEC50	180	nM	EC50	MedChemComm (2016) 7: 2184-2190
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
ChEMBL	Inhibition of HDAC10	B	4.3	pIC50	50100	nM	IC50	Eur. J. Med. Chem. (2012) 53: 390-397 [PMID:22541394]
ChEMBL	Inhibition of HDAC10 by in vitro deacetylation assay	B	4.95	pIC50	11100	nM	IC50	Nat. Chem. Biol. (2010) 6: 25-33 [PMID:19966789]
ChEMBL	Inhibition of HDAC10 (unknown origin) using fluorogenic-(RHKKAc) as substrate by fluorescence assay	B	5.5	pIC50	3150	nM	IC50	Eur J Med Chem (2021) 215: 113169-113169 [PMID:33588178]
ChEMBL	Inhibition of human recombinant HDAC10 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluorescence analysis	B	5.5	pIC50	3150	nM	IC50	Eur J Med Chem (2020) 196: 112291-112291 [PMID:32325365]
ChEMBL	Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay	B	6	pIC50	>1000	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2]
ChEMBL	Inhibition of recombinant C-terminal His-tagged HDAC11 (unknown origin) expressed in baculovirus infected Sf9 cells using Ac-Arg-Gly-Lys(Ac)-AMC as substrate pretreated for 3 hrs followed by substrate addition after 30 mins in presence of 0.2 uM SAHA by fluorometric method	B	5.89	pIC50	1300	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2943-2945 [PMID:28501514]
ChEMBL	Inhibition of recombinant C-terminal His-tagged HDAC11 (unknown origin) expressed in baculovirus infected Sf9 cells using Ac-Arg-Gly-Lys(Ac)-AMC as substrate pretreated for 3 hrs followed by substrate addition after 30 mins by fluorometric method	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2943-2945 [PMID:28501514]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
ChEMBL	Inhibition of human HDAC2	B	7.19	pKi	65	nM	Ki	Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
GtoPdb	-	-	7.19	pKi	65	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of HDAC2	B	5.82	pIC50	1510	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 1926-1930 [PMID:22321215]
ChEMBL	Inhibition of HDAC2	B	6	pIC50	1000	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 110-116 [PMID:21145737]
ChEMBL	Inhibition of FLAG-tagged HDAC2 (unknown origin) expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection based assay	B	6.13	pIC50	740	nM	IC50	Eur J Med Chem (2018) 144: 612-625 [PMID:29289885]
ChEMBL	Inhibition of recombinant human full length HDAC2 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysis	B	6.13	pIC50	740	nM	IC50	Eur J Med Chem (2017) 134: 13-23 [PMID:28395150]
ChEMBL	HDAC enzyme inhibitionAssay: HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48 and Perez-Balado et al., 2007, J. Med. Chem., 50:2497-2505. Inhibition assays using nuclear extract were performed essentially as described in Herman et al., 2006, Nat. Chem. Biol., 2:551-558. Briefly, the purified HDACs or nuclear extract were incubated with an acetylated substrate in the absence of the compound to be assayed and with increasing concentrations of the compound. The rate of substrate deacetylation was measured under each condition, and half-maximal inhibitory concentration with regard to each HDAC was determined by standard means.	B	6.14	pIC50	720	nM	IC50	US-9265734-B2. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors (2016)
ChEMBL	Inhibition of human recombinant His-tagged HDAC2 (1 to 582 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS Green as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence method	B	6.17	pIC50	670	nM	IC50	Eur J Med Chem (2019) 173: 185-202 [PMID:31003060]
ChEMBL	Inhibition of recombinant HDAC2 (unknown origin) incubated for 10 mins using Boc-Lys(acetyl)-AMC fluorogenic substrate by homogeneous fluorescence release assay	B	6.19	pIC50	650	nM	IC50	Bioorg. Med. Chem. (2015) 23: 3457-3471 [PMID:25953722]
ChEMBL	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	B	6.19	pIC50	650	nM	IC50	Eur. J. Med. Chem. (2015) 96: 1-13 [PMID:25874326]
ChEMBL	Inhibition of human HDAC2 using RHKKAc as substrate by fluorescence assay	B	6.21	pIC50	613	nM	IC50	Eur J Med Chem (2019) 162: 612-630 [PMID:30476825]
ChEMBL	Inhibition of HDAC2 (unknown origin) using fluorogenic-(RHKKAc) as substrate by fluorescence assay	B	6.21	pIC50	613	nM	IC50	Eur J Med Chem (2021) 215: 113169-113169 [PMID:33588178]
ChEMBL	Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluorescence analysis	B	6.21	pIC50	613	nM	IC50	Eur J Med Chem (2020) 196: 112291-112291 [PMID:32325365]
ChEMBL	Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected insect cells using RHKKAc-AMC as substrate measured after 60 mins by fluorescence assay	B	6.21	pIC50	610	nM	IC50	Eur J Med Chem (2020) 192: 112158-112158 [PMID:32171161]
ChEMBL	Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-acetyl)-AMC as substrate incubated for 90 mins by fluorescence assay	B	6.3	pIC50	505	nM	IC50	J Med Chem (2019) 62: 11260-11279 [PMID:31762274]
ChEMBL	Inhibition of HDAC2 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by fluorescence analysis	B	6.3	pIC50	505	nM	IC50	Bioorg Med Chem (2017) 25: 4123-4132 [PMID:28629630]
ChEMBL	Inhibition of human recombinant HDAC2	B	6.3	pIC50	500	nM	IC50	J. Med. Chem. (2007) 50: 5543-5546 [PMID:17941625]
ChEMBL	Inhibition of HDAC2 by in vitro deacetylation assay	B	6.3	pIC50	500	nM	IC50	Nat. Chem. Biol. (2010) 6: 25-33 [PMID:19966789]
ChEMBL	Inhibition of human recombinant HDAC2 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by fluorescence assay	B	6.32	pIC50	480	nM	IC50	Eur J Med Chem (2018) 143: 320-333 [PMID:29202397]
ChEMBL	Inhibition of human recombinant C-terminal FLAG-tagged HDAC2 using Boc-Lys-(epsilon-Ac)-AMC as fluorogenic substrate incubated for 90 mins by fluorescence based assay	B	6.39	pIC50	410	nM	IC50	Eur J Med Chem (2019) 177: 457-466 [PMID:31181405]
ChEMBL	Inhibition of HDAC2 (unknown origin) using fluorogenic Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence-based assay	B	6.4	pIC50	400	nM	IC50	J Med Chem (2018) 61: 5304-5322 [PMID:29787262]
ChEMBL	Inhibition of HDAC2 (unknown origin) using Boc-Lys (acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition measured after 1 hr by fluorescence assay	B	6.4	pIC50	396	nM	IC50	Bioorg Med Chem (2017) 25: 2981-2994 [PMID:28511906]
ChEMBL	Inhibition of HDAC2	B	6.47	pIC50	340	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 726-731 [PMID:18060775]
ChEMBL	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	B	6.52	pIC50	<300	nM	IC50	J. Med. Chem. (2013) 56: 4816-4820 [PMID:23672185]
ChEMBL	Inhibition of HDAC2	B	6.6	pIC50	250	nM	IC50	J. Med. Chem. (2008) 51: 2350-2353 [PMID:18370373]
ChEMBL	Inhibition of human C-terminal FLAG-tagged HDAC2 in HEK293 cells	B	6.6	pIC50	250	nM	IC50	J. Med. Chem. (2009) 52: 3453-3456 [PMID:19441846]
ChEMBL	Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay	B	6.61	pIC50	247	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of recombinant human HDAC2 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs by fluorescence based micro plate reader analysis	B	6.97	pIC50	108.2	nM	IC50	J Med Chem (2020) 63: 5501-5525 [PMID:32321249]
ChEMBL	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	B	7	pIC50	<100	nM	IC50	Bioorg. Med. Chem. (2012) 20: 4430-4436 [PMID:22705022]
ChEMBL	Inhibition of HDAC2	B	7.82	pIC50	15	nM	IC50	Bioorg. Med. Chem. (2010) 18: 4103-4110 [PMID:20472442]
ChEMBL	Inhibition of recombinant human HDAC2 using pan-HDAC substrate incubated for 3 hrs by fluorescence method	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
ChEMBL	Inhibition of recombinant human N-terminal GST/flag-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells after 3 hrs by fluorescence assay	B	5.92	pEC50	1200	nM	EC50	MedChemComm (2016) 7: 2184-2190
GtoPdb	-	-	5.94	pEC50	1155	nM	EC50	Biochem J (2008) 409: 581-9 [PMID:17868033]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
GtoPdb	-	-	6.44	pKi	360	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC3	B	6.44	pKi	360	nM	Ki	Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of HADC3 (unknown origin)	B	5.77	pIC50	1700	nM	IC50