compound 11d [PMID: 23981898] [Ligand Id: 6946] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2425612
  • beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
Created with Highcharts 10.3.3ValuesChart context menuBeta-secretase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCathepsin DpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing wild type APP B 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (2013) 23: 5300-5306 [PMID:23981898]
ChEMBL Inhibition of human BACE1 B 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2013) 23: 5300-5306 [PMID:23981898]
GtoPdb - - 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2013) 23: 5300-6 [PMID:23981898]
cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339]
ChEMBL Inhibition of human cathepsin-D B 6.09 pIC50 820 nM IC50 Bioorg Med Chem Lett (2013) 23: 5300-5306 [PMID:23981898]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]