ChEMBL ligand: CHEMBL2333941 (J3.079.793K, Ly-2811376, Ly2811376, LY2811376)
beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] beta-secretase 1/Beta-secretase 1 in Mouse [ChEMBL: CHEMBL4593] [GtoPdb: 2330] [UniProtKB: P56818] There should be some charts here, you may need to enable JavaScript!
beta-secretase 2/Beta secretase 2 in Human [ChEMBL: CHEMBL2525] [GtoPdb: 2331] [UniProtKB: Q9Y5Z0] There should be some charts here, you may need to enable JavaScript!
cathepsin D/Cathepsin D in Human [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL	Inhibition of human BACE1 using MOCA-SEV-NL-DAEFR-DNP-RR as substrate measured after 2 hrs by FRET assay	B	6.21	pIC50	620	nM	IC50	J Nat Prod (2018) 81: 1937-1945 [PMID:30207465]
ChEMBL	Inhibition of BACE1 (unknown origin) by HTRF assay	B	6.24	pIC50	571	nM	IC50	ACS Med Chem Lett (2023) 14: 223-228 [PMID:36793434]
ChEMBL	Inhibition of BACE-1 in HEK293 cells expressing human APP751 cDNA harboring N670L671 mutation pretreated for 2 hrs followed by measuring after 2 hrs by sandwich ELISA	B	6.52	pIC50	300	nM	IC50	J Med Chem (2018) 61: 619-637 [PMID:28749667]
ChEMBL	Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incubated for 19 hrs by microplate reader analysis	B	6.57	pIC50	270	nM	IC50	ACS Med Chem Lett (2016) 7: 271-276 [PMID:26985314]
ChEMBL	Inhibition of BACE1 (unknown origin)	B	6.57	pIC50	270	nM	IC50	Bioorg Med Chem Lett (2019) 29: 761-777 [PMID:30709653]
ChEMBL	Inhibition of human recombinant BACE1 using MBP-C125Swe as substrate	B	6.57	pIC50	270	nM	IC50	Bioorg Med Chem Lett (2016) 26: 5729-5731 [PMID:27816517]
ChEMBL	Inhibition of human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using Rh-EVNLDAEFK-quencher as substrate measured after 90 mins by FRET assay	B	6.57	pIC50	269.3	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126772-126772 [PMID:31711785]
ChEMBL	Inhibition of BACE1 (unknown origin) using beta-secretase as substrate incubated in dark for 1 hr by fluorescence based analysis	B	6.59	pIC50	260	nM	IC50	Eur J Med Chem (2021) 209: 112860-112860 [PMID:33032085]
ChEMBL	Inhibition of recombinant human BACE1 by 7-methoxycoumarin-4-yl-acetyl-based FRET assay	B	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2033-2045 [PMID:24704031]
ChEMBL	Inhibition of IgG1 Fc-fused human recombinant BACE1 (1 to 460 residues) expressed in HEK293 cells using methylcoumarin peptide harboring Swedish mutant as substrate incubated for 20 hrs by FRET assay	B	6.62	pIC50	240	nM	IC50	ACS Med Chem Lett (2016) 7: 271-276 [PMID:26985314]
ChEMBL	Inhibition of human BACE-1	B	6.62	pIC50	240	nM	IC50	J Med Chem (2018) 61: 619-637 [PMID:28749667]
GtoPdb	-	-	6.62	pIC50	239	nM	IC50	J Neurosci (2011) 31: 16507-16 [PMID:22090477]
ChEMBL	Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by FRET assay	B	6.62	pIC50	239	nM	IC50	Bioorg Med Chem (2020) 28: 115194-115194 [PMID:31786008]
ChEMBL	Inhibition of recombinant human BACE1 using (MCA)-S-E-V-N-L-D-A-E-F-R-K(dinitrophenol)-R-R-R-R-NH2 as substrate incubated for 8 hrs by FRET assay	B	6.62	pIC50	239	nM	IC50	J Med Chem (2021) 64: 8076-8100 [PMID:34081466]
ChEMBL	Inhibition of human BACE1	B	6.62	pIC50	239	nM	IC50	J Med Chem (2018) 61: 4476-4504 [PMID:29613789]
ChEMBL	Inhibition of BACE 1 (unknown origin) using 250 nM of Rh-EVNLDAEFK-Quencher as substrate after 1 hr by FRET assay	B	6.76	pIC50	173	nM	IC50	Bioorg Med Chem (2018) 26: 4823-4840 [PMID:30181028]
ChEMBL	Inhibition of BACE1 in HEK293 cells expressing APPswedish mutant assessed as inhibition of amyloid beta production by ELISA	B	6.52	pEC50	300	nM	EC50	Bioorg Med Chem Lett (2014) 24: 2033-2045 [PMID:24704031]
beta-secretase 1/Beta-secretase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4593] [GtoPdb: 2330] [UniProtKB: P56818]
ChEMBL	Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assay	B	6.9	pIC50	126	nM	IC50	J Med Chem (2021) 64: 8076-8100 [PMID:34081466]
beta-secretase 2/Beta secretase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2525] [GtoPdb: 2331] [UniProtKB: Q9Y5Z0]
ChEMBL	Inhibition of human BACE2	B	6.54	pIC50	288	nM	IC50	Bioorg Med Chem (2020) 28: 115194-115194 [PMID:31786008]
cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339]
ChEMBL	Inhibition of human cathepsin D	B	4.8	pIC50	15700	nM	IC50	Bioorg Med Chem (2020) 28: 115194-115194 [PMID:31786008]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]