ChEMBL ligand: CHEMBL1464 (NSC-59813, Warfarin)
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874] There should be some charts here, you may need to enable JavaScript!
proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549] There should be some charts here, you may need to enable JavaScript!
vitamin K epoxide reductase complex subunit 1/Vitamin k epoxide reductase complex subunit 1 isoform 1 in Human [ChEMBL: CHEMBL1930] [GtoPdb: 2645] [UniProtKB: Q9BQB6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL	Tested for the HIV Protease inhibitory activity of the compound	F	4.52	pIC50	~30000	nM	IC50	J Med Chem (1994) 37: 3200-3204 [PMID:7932546]
proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549]
ChEMBL	Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubated for 1 hr measured after 1 hr at 1 min interval by fluorescence assay	B	4.61	pIC50	24590	nM	IC50	J Nat Prod (2011) 74: 1353-1357 [PMID:21510613]
vitamin K epoxide reductase complex subunit 1/Vitamin k epoxide reductase complex subunit 1 isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1930] [GtoPdb: 2645] [UniProtKB: Q9BQB6]
GtoPdb	-	-	5.58	pKi	2633	nM	Ki	Biochim Biophys Acta (2013) 1830: 4202-10 [PMID:23618698]
ChEMBL	Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA	B	8.06	pIC50	8.8	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1954-1956 [PMID:31147103]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]