ChEMBL ligand: CHEMBL467 (Droxia, Hidroxicarbamida, Hydrea, Hydroxycarbamide, Hydroxyurea, NSC-32065, Siklos, SQ 1089, SQ-1089)
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
Urease subunit alpha/Urease subunit beta in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL3885651] [UniProtKB: P14916, P69996]
ribonucleotide reductase catalytic subunit M1 in Human [GtoPdb: 2630] [UniProtKB: P23921]
ribonucleotide reductase regulatory subunit M2 in Human [GtoPdb: 2631] [UniProtKB: P31350]

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of human CA2	B	4.55	pKi	28000	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4316-4320 [PMID:16759856]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of human CA9	B	4.64	pKi	23000	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4316-4320 [PMID:16759856]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL	Inhibition of human CA5a	B	4.51	pKi	31000	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4316-4320 [PMID:16759856]
Urease subunit alpha/Urease subunit beta in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885651] [UniProtKB: P14916, P69996]
ChEMBL	Inhibition of Helicobacter pylori urease	B	4	pIC50	100000	nM	IC50	Eur J Med Chem (2022) 234: 114273-114273 [PMID:35305460]
ribonucleotide reductase catalytic subunit M1 in Human [GtoPdb: 2630] [UniProtKB: P23921]
GtoPdb	Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme	-	3.83	pIC50	148000	nM	IC50	Biochem Pharmacol (2005) 69: 627-34 [PMID:15670581]
ribonucleotide reductase regulatory subunit M2 in Human [GtoPdb: 2631] [UniProtKB: P31350]
GtoPdb	Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme	-	3.83	pIC50	148000	nM	IC50	Biochem Pharmacol (2005) 69: 627-34 [PMID:15670581]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]