ChEMBL ligand: CHEMBL1466 (Bishydroxycoumarin, Dicoumarol, Dicoumarolum, Dicumarol, NSC-17860, NSC-221570, NSC-41834)
aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!
ATP phosphoribosyltransferase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6086] [UniProtKB: P9WMN1] There should be some charts here, you may need to enable JavaScript!
CYP2C9/Cytochrome P450 2C9 in Human [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712] There should be some charts here, you may need to enable JavaScript!
Enoyl-[acyl-carrier-protein] reductase [NADH] in Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) [ChEMBL: CHEMBL2150835] [UniProtKB: Q5NGQ3] There should be some charts here, you may need to enable JavaScript!
GPR35/G-protein coupled receptor 35 in Human [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
NAD(P)H dehydrogenase [quinone] 1 in Rat [ChEMBL: CHEMBL3091269] [UniProtKB: P05982] There should be some charts here, you may need to enable JavaScript!
Quinone reductase 1) in Human [ChEMBL: CHEMBL3623] [UniProtKB: P15559] There should be some charts here, you may need to enable JavaScript!
proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549] There should be some charts here, you may need to enable JavaScript!
Urease in Canavalia ensiformis [ChEMBL: CHEMBL4161] [UniProtKB: P07374] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde)	B	5.39	pIC50	4093	nM	IC50	DrugMatrix in vitro pharmacology data
ATP phosphoribosyltransferase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6086] [UniProtKB: P9WMN1]
ChEMBL	Inhibition of Mycobacterium tuberculosis HisG assessed as phosphoribosyl ATP production by spectrophotometry	B	4.22	pKi	60000	nM	Ki	J Med Chem (2008) 51: 5984-5992 [PMID:18778048]
CYP2C9/Cytochrome P450 2C9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712]
ChEMBL	DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	6.52	pIC50	300	nM	IC50	DrugMatrix in vitro pharmacology data
Enoyl-[acyl-carrier-protein] reductase [NADH] in Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150835] [UniProtKB: Q5NGQ3]
ChEMBL	Inhibition of C-terminal His6-tagged Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrate assessed as oxidation of NADH to NAD+ by fluorescence assay	B	4.33	pIC50	47000	nM	IC50	J Med Chem (2013) 56: 5275-5287 [PMID:23815100]
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL	Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis	B	7.41	pKi	39	nM	Ki	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL	Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay	B	5.01	pEC50	9780	nM	EC50	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL	Agonist activity at human GPR35 expressed in HEK293T cells at 5 uM by EYPF-based beta-arrestin-2 luciferase reporter gene assay	B	5.89	pEC50	1300	nM	EC50	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL	Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay	B	5.89	pEC50	1300	nM	EC50	J Med Chem (2017) 60: 362-372 [PMID:27976894]
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL	Inhibitory activity against 3'-processing of DNA by HIV-1 integrase	F	4	pIC50	>100000	nM	IC50	J Med Chem (1997) 40: 242-249 [PMID:9003523]
ChEMBL	Integration of DNA by HIV -1 integrase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1997) 40: 242-249 [PMID:9003523]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)	B	5.35	pIC50	4426	nM	IC50	DrugMatrix in vitro pharmacology data
NAD(P)H dehydrogenase [quinone] 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3091269] [UniProtKB: P05982]
ChEMBL	Competitive binding affinity to rat liver NQO1 in presence of NADPH	B	9	pKi	1	nM	Ki	J Med Chem (2018) 61: 6983-7003 [PMID:29712428]
Quinone reductase 1) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3623] [UniProtKB: P15559]
ChEMBL	Inhibition of human recombinant NQO1	B	6.35	pIC50	450	nM	IC50	Bioorg Med Chem Lett (2006) 16: 6246-6254 [PMID:17011189]
ChEMBL	Inhibition of human recombinant NQO1 in presence of BSA	B	6.35	pIC50	450	nM	IC50	J Med Chem (2007) 50: 6316-6325 [PMID:17999461]
ChEMBL	Inhibition of human recombinant NQO1 in presence of BSA	B	6.39	pIC50	404	nM	IC50	J Med Chem (2009) 52: 7142-7156 [PMID:19877692]
ChEMBL	Inhibition of recombinant human NQO1 assessed as reduction in oxidation of NADPH to NADP+ using b-lap as substrate and NADPH in presence of 0.14% (w/v) BSA	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2017) 127: 828-839 [PMID:27829520]
ChEMBL	Inhibition of human recombinant NQO1	B	8.3	pIC50	5	nM	IC50	J Med Chem (2007) 50: 6316-6325 [PMID:17999461]
ChEMBL	Inhibition of human recombinant NQO1	B	8.59	pIC50	2.6	nM	IC50	J Med Chem (2009) 52: 7142-7156 [PMID:19877692]
proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549]
ChEMBL	Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubated for 1 hr measured after 1 hr at 1 min interval by fluorescence assay	B	5.89	pIC50	1300	nM	IC50	J Nat Prod (2011) 74: 1353-1357 [PMID:21510613]
Urease in Canavalia ensiformis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4161] [UniProtKB: P07374]
ChEMBL	Inhibition of jack bean urease	B	4.82	pIC50	15135.61	nM	IC50	Bioorg Med Chem (2008) 16: 3456-3461 [PMID:18280742]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]