bradyzide [Ligand Id: 680] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL308468 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411] | ||||||||
| ChEMBL | Displacement of [3H]BK (1 nM) from human Bradykinin receptor B2 expressed in Cos-7 cells | B | 6.11 | pKi | 772 | nM | Ki | J Med Chem (2002) 45: 2160-2172 [PMID:12014954] |
| GtoPdb | - | - | 6.5 | pKi | - | - | - | Br J Pharmacol (2000) 129: 77-86 [PMID:10694205] |
| B2 receptor/Bradykinin B2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2501] [GtoPdb: 42] [UniProtKB: P25023] | ||||||||
| ChEMBL | Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranes | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2002) 45: 2160-2172 [PMID:12014954] |
| GtoPdb | - | - | 9.5 | pKi | - | - | - | Br J Pharmacol (2000) 129: 77-86 [PMID:10694205] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
