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ChEMBL ligand: CHEMBL304858 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] | ||||||||
ChEMBL | Inhibition of oxidosqualene cyclase | B | 6.65 | pIC50 | 223.87 | nM | IC50 | Eur J Med Chem (2008) 43: 1462-1468 [PMID:17981368] |
ChEMBL | Inhibition of human C-terminal His6-tagged OSC expressed in Pichia pastoris GS115 using 2,3-oxidosqualene as substrate after 90 mins by 1H NMR method | B | 8.12 | pIC50 | 7.5 | nM | IC50 | J Med Chem (2018) 61: 5047-5053 [PMID:29771525] |
ChEMBL | Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomes | B | 8.19 | pIC50 | 6.5 | nM | IC50 | J Med Chem (2003) 46: 2083-2092 [PMID:12747780] |
ChEMBL | Inhibition of oxidosqualene cyclase | B | 8.19 | pIC50 | 6.46 | nM | IC50 | J Med Chem (2007) 50: 5039-5042 [PMID:17760433] |
GtoPdb | - | - | 8.24 | pIC50 | 5.7 | nM | IC50 | J Med Chem (2012) 55: 4990-5002 [PMID:22533316] |
Squalene-hopene cyclase in Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3569] [UniProtKB: P33247] | ||||||||
ChEMBL | Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2003) 46: 2083-2092 [PMID:12747780] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]