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ChEMBL ligand: CHEMBL481608 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Cycloartenol synthase in Arabidopsis thaliana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5356] [UniProtKB: P38605] | ||||||||
ChEMBL | Inhibition of Arabidopsis thaliana cycloartenol synthase expressed in Saccharomyces cerevisiae SMY8 | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 718-723 [PMID:19119009] |
lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] | ||||||||
ChEMBL | Inhibition of human OSC expressed in Saccharomyces cerevisiae SMY8 | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 718-723 [PMID:19119009] |
ChEMBL | Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imaging | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2012) 55: 4990-5002 [PMID:22533316] |
GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2012) 55: 4990-5002 [PMID:22533316] |
Lanosterol synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5355] [UniProtKB: P38604] | ||||||||
ChEMBL | Inhibition of yeast OSC expressed in Saccharomyces cerevisiae SMY8 | B | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 718-723 [PMID:19119009] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]