[3H]-di-o-tolylguanidine [Ligand Id: 6685] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL282433 (Di-o-tolylguanidine, Ditolylguanidine)
  • 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human [ChEMBL: CHEMBL4931] [UniProtKB: Q15125]
  • 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Guinea pig [ChEMBL: CHEMBL5525] [UniProtKB: Q60490]
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  • C-8 sterol isomerase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL3224] [UniProtKB: P32352]
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Rat [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Rat [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
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  • Vesicular acetylcholine transporter in Rat [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4931] [UniProtKB: Q15125]
ChEMBL Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand B 5.17 pKi 6700 nM Ki J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5525] [UniProtKB: Q60490]
ChEMBL Displacement of [3H](-)-(S)-emopamil from EBP in guinea pig liver membrane B 5.12 pKi 7660 nM Ki J Med Chem (2008) 51: 7523-7531 [PMID:19053780]
C-8 sterol isomerase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3224] [UniProtKB: P32352]
ChEMBL Affinity for ERG2 of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand B 5.7 pKi 2000 nM Ki J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5]
ChEMBL In vitro inhibitory activity against [3H](+)-MK-801 binding to PCP receptor in guinea pig brain membrane homogenates B 4.97 pIC50 10700 nM IC50 J Med Chem (1990) 33: 2421-2429 [PMID:1975275]
ChEMBL In vitro inhibitory activity against [3H]-TCP binding to PCP receptor in guinea pig brain membrane homogenates B 5.11 pIC50 7800 nM IC50 J Med Chem (1990) 33: 2421-2429 [PMID:1975275]
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL Binding affinity was measured as selectivity for sigma-1 site over phencyclidine (PCP) receptor in rat using [3H]TCP as radioligand B 5.17 pKi 6690 nM Ki J Med Chem (1994) 37: 1964-1970 [PMID:8027978]
ChEMBL In vitro concentration required to inhibit specific [3H]MK-801 radioligand binding to N-methyl-D-aspartate (NMDA) receptor on rat brain membrane B 5.04 pIC50 9120 nM IC50 J Med Chem (1994) 37: 260-267 [PMID:8295213]
M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
ChEMBL Binding affinity was measured as selectivity for sigma-1 site over muscarinic (M1) receptor in rat B 6.13 pKi 744 nM Ki J Med Chem (1994) 37: 1964-1970 [PMID:8027978]
M2 receptor/Muscarinic acetylcholine receptor M2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
ChEMBL Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand B 5.53 pKi 2960 nM Ki J Med Chem (1994) 37: 1964-1970 [PMID:8027978]
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 opioid receptor in guinea pig brain membrane B 6.75 pKi 177.3 nM Ki Bioorg Med Chem (2008) 16: 2992-3001 [PMID:18221879]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 2 hrs by scintillation counting B 6.75 pKi 177 nM Ki Bioorg Med Chem (2016) 24: 4045-4055 [PMID:27396684]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by liquid scintillation analyzer B 6.79 pKi 164 nM Ki Eur J Med Chem (2009) 44: 519-525 [PMID:18499305]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane B 6.79 pKi 164 nM Ki Eur J Med Chem (2007) 42: 1247-1262 [PMID:17420073]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by solid scintillation counting method B 7.05 pKi 89 nM Ki Eur J Med Chem (2021) 219: 113443-113443 [PMID:33901806]
ChEMBL Displacement of [3H](+)-pentazocine from sigma1 opioid receptor from guinea pig brain cortex after 150 mins by scintillation counting B 7.05 pKi 89 nM Ki Bioorg Med Chem (2010) 18: 4095-4102 [PMID:20451396]
ChEMBL Displacement of [3H](+)-pentazocine from sigma1 receptor guinea pig brain after 180 mins scintillation counting B 7.05 pKi 89 nM Ki Bioorg Med Chem (2010) 18: 8005-8015 [PMID:20965739]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes B 7.05 pKi 89 nM Ki Eur J Med Chem (2011) 46: 1972-1982 [PMID:21481987]
ChEMBL Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis B 7.05 pKi 89 nM Ki Bioorg Med Chem (2013) 21: 1844-1856 [PMID:23462714]
ChEMBL Displacement of (+)-pentazocine from sigma-1 receptor in guinea pig brain cortex membrane after 120 mins by scintillation counting B 7.05 pKi 89 nM Ki Eur J Med Chem (2013) 69: 490-497 [PMID:24095744]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting B 7.05 pKi 89 nM Ki Eur J Med Chem (2013) 70: 78-87 [PMID:24140950]
ChEMBL Displacement of (+)-pentazocine from sigma1 receptor in guinea pig brain cortex membrane by scintillation counting analysis B 7.05 pKi 89 nM Ki Eur J Med Chem (2014) 83: 526-533 [PMID:24996139]
ChEMBL Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method B 7.05 pKi 89 nM Ki Bioorg Med Chem (2014) 22: 6638-6646 [PMID:25458498]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain cortex membranes B 7.05 pKi 89 nM Ki Bioorg Med Chem (2014) 22: 4277-4284 [PMID:24913984]
ChEMBL Displacement of [3H]-(+)-Pentazocine from sigma1 receptor in guniea pig brain cortex membranes by scintillation counting analysis B 7.05 pKi 89 nM Ki Bioorg Med Chem Lett (2015) 25: 5748-5751 [PMID:26531150]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation spectrometry B 7.05 pKi 89 nM Ki Medchemcomm (2016) 7: 327-331
ChEMBL Displacement of [3H]-(+)-Pentazocine from sigma1 receptor in guinea pig brain homogenate incubated for 120 mins by solid scintillation counting analysis B 7.05 pKi 89 nM Ki Eur J Med Chem (2016) 116: 136-146 [PMID:27061977]
ChEMBL Displacement of [3H]-pentazocine from sigma1 receptor in guinea pig brain membranes after 120 mins by liquid scintillation counting B 7.05 pKi 89 nM Ki Bioorg Med Chem (2017) 25: 4778-4799 [PMID:28764962]
ChEMBL Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis B 7.05 pKi 89 nM Ki Bioorg Med Chem (2017) 25: 5365-5372 [PMID:28797770]
ChEMBL Displacement of [3H]-(+)-Pentazocine from sigma 1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting analysis B 7.05 pKi 89 nM Ki Bioorg Med Chem (2018) 26: 501-508 [PMID:29254894]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes measured after 120 mins by scintillation counting method B 7.05 pKi 89 nM Ki Bioorg Med Chem (2018) 26: 1705-1712 [PMID:29482951]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain cortex membranes incubated for 120 mins measured for 5 mins by scintillation counting method B 7.05 pKi 89 nM Ki Eur J Med Chem (2018) 144: 672-681 [PMID:29289890]
ChEMBL Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis B 7.05 pKi 89 nM Ki Medchemcomm (2017) 8: 975-981 [PMID:30108812]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting method B 7.05 pKi 89 nM Ki Eur J Med Chem (2019) 180: 268-282 [PMID:31319263]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting method B 7.05 pKi 89 nM Ki Bioorg Med Chem (2019) 27: 115146-115146 [PMID:31648876]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting method B 7.05 pKi 89 nM Ki Eur J Med Chem (2019) 177: 47-62 [PMID:31129453]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membranes incubated for 120 mins by scintillation counting method B 7.05 pKi 89 nM Ki Bioorg Med Chem (2020) 28: 115245-115245 [PMID:31843460]
ChEMBL Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 120 mins by scintillation counting method B 7.05 pKi 89 nM Ki ACS Med Chem Lett (2020) 11: 651-656 [PMID:32435366]
ChEMBL Displacement of [3H]-pentazocine from sigma1 receptor in guinea pig brain membrane incubated for 120 mins by liquid scintillation counting method B 7.05 pKi 89 nM Ki Eur J Med Chem (2021) 210: 112950-112950 [PMID:33148494]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane without cerebellum B 7.05 pKi 88.5 nM Ki J Med Chem (2008) 51: 7523-7531 [PMID:19053780]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting analysis B 7.15 pKi 71 nM Ki J Med Chem (2019) 62: 4204-4217 [PMID:30939014]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting method B 7.15 pKi 71 nM Ki Eur J Med Chem (2016) 121: 712-726 [PMID:27366902]
ChEMBL Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis B 7.15 pKi 71 nM Ki J Med Chem (2016) 59: 5505-5519 [PMID:27156565]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting analysis B 7.15 pKi 71 nM Ki J Med Chem (2014) 57: 2884-2894 [PMID:24617836]
ChEMBL Displacement of [3H]-pentazocine from guinea pig brain sigma 1 receptor incubated for 120 mins by liquid scintillation counting method B 7.15 pKi 71 nM Ki RSC Med Chem (2021) 12: 237-244 [PMID:34046612]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting method B 7.15 pKi 70.1 nM Ki Eur J Med Chem (2015) 90: 1-9 [PMID:25461306]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins B 7.16 pKi 69.4 nM Ki J Med Chem (2011) 54: 3669-3673 [PMID:21476493]
ChEMBL Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membrane B 7.21 pKi 61 nM Ki J Med Chem (2010) 53: 4212-4222 [PMID:20441176]
ChEMBL Displacement of (+)-[3H]pentazocine from guinea pig brain sigma 1 receptor after 180 mins by scintillation counting B 7.21 pKi 61 nM Ki J Med Chem (2011) 54: 6704-6713 [PMID:21859078]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 180 mins by solid scintillation counting B 7.21 pKi 61 nM Ki Eur J Med Chem (2012) 53: 327-336 [PMID:22578786]
ChEMBL Displacement of [3H]-(+)pentazocine from guinea pig brain sigma 1-type opioid receptor after 120 mins by scintillation counting analysis B 7.21 pKi 61 nM Ki J Med Chem (2012) 55: 5350-5360 [PMID:22515405]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting B 7.21 pKi 61 nM Ki J Med Chem (2012) 55: 8047-8065 [PMID:22913577]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes after 120 mins by microbeta scintillation counting method B 7.21 pKi 61 nM Ki Bioorg Med Chem (2017) 25: 3384-3395 [PMID:28501431]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membrane incubated for 120 mins measured for 5 mins by scintillation counting method B 7.21 pKi 61 nM Ki Bioorg Med Chem (2017) 25: 2472-2481 [PMID:28320613]
ChEMBL Displacement of [3H](+)-pentazocine from opioid sigma1 receptor in guinea pig brain homogenate B 7.21 pKi 61 nM Ki Bioorg Med Chem (2009) 17: 777-793 [PMID:19081725]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane B 7.21 pKi 61 nM Ki J Med Chem (2008) 51: 6531-6537 [PMID:18816044]
ChEMBL Displacement of [3H](+)-pentazocine from sigma1 opioid receptor in guinea pig brain by solid scintillation counting B 7.21 pKi 61 nM Ki Bioorg Med Chem (2009) 17: 1445-1455 [PMID:19196515]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by solid scintillation analysis B 7.21 pKi 61 nM Ki Bioorg Med Chem (2009) 17: 3630-3641 [PMID:19394833]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane after 180 mins by scintillation counting B 7.21 pKi 61 nM Ki J Med Chem (2009) 52: 6062-6072 [PMID:19791807]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain after 180 mins by scintillation counting B 7.21 pKi 61 nM Ki Eur J Med Chem (2009) 44: 4306-4314 [PMID:19709783]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by scintillation analysis B 7.21 pKi 61 nM Ki J Med Chem (2009) 52: 2126-2137 [PMID:19243173]
ChEMBL Displacement of [3H]-(+)-pentazocine from guinea pig brain sigma-1 receptor after 180 mins by scintillation counting analysis B 7.21 pKi 61 nM Ki Medchemcomm (2012) 3: 673-679
ChEMBL Displacement of (+)-[3H]pentazocine from sigma 1 receptor in guinea pig brain homogenate after 120 mins by beta counting B 7.23 pKi >58.8 nM Ki Bioorg Med Chem (2015) 23: 1463-1471 [PMID:25752422]
ChEMBL Displacement of [3H](+)-pentazocine from guinea pig brain sigma 1 receptor B 7.39 pKi 41 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
ChEMBL Displacement of [3H](+)pentazocine from sigma1 receptor in Dunkin Hartley guinea pig brain membrane after 120 mins by liquid scintillation counting analysis B 7.42 pKi 38.4 nM Ki Eur J Med Chem (2013) 64: 488-497 [PMID:23680866]
ChEMBL Displacement of [3H](+)-pentazocine from Sigma1 receptor in Dunkin Hartley guinea pig brain membrane after 120 mins by liquid scintillation counting analysis B 7.44 pKi 36.7 nM Ki Bioorg Med Chem Lett (2016) 26: 2676-2679 [PMID:27090556]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysis B 7.45 pKi 35.45 nM Ki Bioorg Med Chem (2015) 23: 222-230 [PMID:25468036]
σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2]
ChEMBL Binding affinity to sigma 2 receptor (unknown origin) B 7.55 pKi 28.4 nM Ki J Med Chem (2016) 59: 6329-6343 [PMID:27309376]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in human RT4 cell membranes incubated for 120 mins in the presence of sigma1 receptor ligand (+)-pentazocine by scintillation counting method B 7.7 pKi 20 nM Ki J Med Chem (2019) 62: 4204-4217 [PMID:30939014]
σ2/Sigma intracellular receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7]
ChEMBL Binding affinity to sigma2 receptor in rat liver membranes incubated for 120 mins by liquid scintillation counting method B 7.75 pKd 17.9 nM Kd Eur J Med Chem (2019) 177: 47-62 [PMID:31129453]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membrane by solid scintillation counting method B 7.24 pKi 58 nM Ki Eur J Med Chem (2021) 219: 113443-113443 [PMID:33901806]
ChEMBL Displacement of [3H]-DTG from sigma2 receptor in rat liver membranes after 120 mins by liquid scintillation counting B 7.24 pKi 58 nM Ki Bioorg Med Chem (2017) 25: 4778-4799 [PMID:28764962]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membrane incubated for 120 mins by liquid scintillation counting method relative to control B 7.24 pKi 58 nM Ki Eur J Med Chem (2021) 210: 112950-112950 [PMID:33148494]
ChEMBL Displacement of [3H]-DTG from sigma 2 receptor in rat liver membranes after 120 mins by scintillation counting analysis B 7.24 pKi 58 nM Ki Bioorg Med Chem (2018) 26: 501-508 [PMID:29254894]
ChEMBL Displacement of [3H]di-o-tolylguanidine from sigma2 receptor in rat liver membranes measured after 120 mins by solid scintillation counting method B 7.24 pKi 57 nM Ki Bioorg Med Chem (2019) 27: 115146-115146 [PMID:31648876]
ChEMBL Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting method B 7.24 pKi 57 nM Ki Bioorg Med Chem (2018) 26: 1705-1712 [PMID:29482951]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma-2 receptor in rat liver membranes incubated for 120 mins measured for 5 mins by scintillation counting method B 7.24 pKi 57 nM Ki Eur J Med Chem (2018) 144: 672-681 [PMID:29289890]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes in the presence of sigma1 receptor ligand (+)-pentazocine incubated for 120 mins by scintillation counting method B 7.24 pKi 57 nM Ki Eur J Med Chem (2019) 180: 268-282 [PMID:31319263]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting method B 7.24 pKi 57 nM Ki Eur J Med Chem (2019) 177: 47-62 [PMID:31129453]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins in the presence of sigma1 receptor ligand (+)-pentazocine by scintillation counting method B 7.24 pKi 57 nM Ki Bioorg Med Chem (2020) 28: 115245-115245 [PMID:31843460]
ChEMBL Displacement of [3H]-Di-o-tolylguanidine from sigma-2 receptor in rat liver membranes after 120 mins by scintillation counting method B 7.24 pKi 57 nM Ki ACS Med Chem Lett (2020) 11: 651-656 [PMID:32435366]
ChEMBL Displacement of [3H]DTG from sigma2 receptor in rat liver membranes by liquid scintillation counting method B 7.27 pKi 54 nM Ki Eur J Med Chem (2018) 156: 534-553 [PMID:30025348]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins in the presence of sigma1 receptor ligand (+)-pentazocine by scintillation counting method B 7.27 pKi 54 nM Ki J Med Chem (2019) 62: 4204-4217 [PMID:30939014]
ChEMBL Displacement of [3H]-DTG from Sprague-Dawley rat liver sigma 2 receptor incubated for 120 mins by liquid scintillation counting method B 7.27 pKi 54 nM Ki RSC Med Chem (2021) 12: 237-244 [PMID:34046612]
ChEMBL Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membrane incubated for 120 mins measured for 5 mins by scintillation counting method B 7.38 pKi 42 nM Ki Bioorg Med Chem (2017) 25: 2472-2481 [PMID:28320613]
ChEMBL Displacement of [3H]DTG from sigma-2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting method B 7.38 pKi 42 nM Ki Bioorg Med Chem (2017) 25: 3384-3395 [PMID:28501431]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL Binding affinity against MCF cells in the membrane preparation using radioligand binding assay. B 7.42 pKd 38.2 nM Kd J Med Chem (1994) 37: 1737-1739 [PMID:8021913]
ChEMBL Binding constant (Kd) for [3H]DTG binding to Sigma opioid receptor type 1 of guinea pig brain membranes at 1 uM BNIT B 7.87 pKd 13.6 nM Kd J Med Chem (2002) 45: 2662-2665 [PMID:12036376]
ChEMBL Binding constant (Kd) for [3H]DTG binding to Sigma opioid receptor type 1 of guinea pig brain membranes at 5 uM BNIT B 7.94 pKd 11.6 nM Kd J Med Chem (2002) 45: 2662-2665 [PMID:12036376]
ChEMBL Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in human RPMI8226 cell membranes after 120 mins by scintillation counting analysis B 6.68 pKi 208 nM Ki J Med Chem (2014) 57: 2884-2894 [PMID:24617836]
ChEMBL Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes B 6.68 pKi 208 nM Ki J Med Chem (2016) 59: 5505-5519 [PMID:27156565]
ChEMBL Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand. B 6.79 pKi 164 nM Ki J Med Chem (2002) 45: 438-448 [PMID:11784148]
ChEMBL Affinity at sigma-1 site by inhibition of [3H](+)-pentazocine (PENT) binding in guinea pig brain B 6.97 pKi 107 nM Ki J Med Chem (1994) 37: 1964-1970 [PMID:8027978]
ChEMBL Binding affinity for Sigma opioid receptor type 1 in guinea pig brain homogenate with 0.5 nM [3H](+)-PENT B 6.97 pKi 107 nM Ki Bioorg Med Chem Lett (1994) 4: 2185-2188
ChEMBL Binding affinity to sigma-1 receptor (unknown origin) by radioligand displacement assay B 7.05 pKi 89 nM Ki Bioorg Med Chem Lett (2016) 26: 889-893 [PMID:26750254]
ChEMBL Binding affinity for Sigma opioid receptor type 2 in guinea pig brain homogenate with 4 nM [3H]-(+)-DTG B 7.15 pKi 70 nM Ki Bioorg Med Chem Lett (1994) 4: 2185-2188
ChEMBL Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocine B 7.16 pKi 69 nM Ki J Med Chem (2005) 48: 266-273 [PMID:15634021]
ChEMBL Binding affinity against sigma receptor of MCF cells B 7.22 pKi 60 nM Ki J Med Chem (1994) 37: 1737-1739 [PMID:8021913]
ChEMBL Displacement of [3H]-(+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation counting method B 7.23 pKi 59 nM Ki J Med Chem (2020) 63: 14979-14988 [PMID:33237785]
ChEMBL Tested for binding affinity against sigma 1 receptor B 7.39 pKi 41 nM Ki J Med Chem (1994) 37: 1214-1219 [PMID:8164264]
ChEMBL Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using [3H]DTG as radioligand B 7.43 pKi 37.3 nM Ki J Med Chem (1996) 39: 176-182 [PMID:8568804]
ChEMBL Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane. B 7.54 pKi 28.8 nM Ki J Med Chem (1991) 34: 1855-1859 [PMID:1648139]
ChEMBL In vitro binding affinity at opioid sigma-1 receptor in guinea pig brain membranes by (+)-[3H]pentazocine displacement. B 7.55 pKi 28.2 nM Ki J Med Chem (2004) 47: 2308-2317 [PMID:15084129]
ChEMBL Ability to displace [3H](+)-pentazocine at sigma receptor in guinea pig brain membrane was determined B 7.55 pKi 28 nM Ki J Med Chem (1993) 36: 2311-2320 [PMID:8360875]
ChEMBL Binding affinity for sigma receptor using [3H](+)-pentazocine in guinea pig brain homogenates B 7.56 pKi 27.7 nM Ki J Med Chem (1992) 35: 4334-4343 [PMID:1447735]
ChEMBL Binding affinity towards sigma 1 receptor was determined in guinea pig brain membrane using [3H](+)-pentazocine as radioligand B 7.56 pKi 27.7 nM Ki J Med Chem (1994) 37: 314-321 [PMID:8295220]
ChEMBL Inhibition of [3H]pentazocine binding to Sigma opioid receptor type 1 B 7.56 pKi 27.4 nM Ki Bioorg Med Chem Lett (1997) 7: 2303-2306
ChEMBL Inhibitory constant against sigma receptor type 2 using 3 nM [3H]ditolylguanidine B 7.68 pKi 21 nM Ki J Med Chem (2005) 48: 266-273 [PMID:15634021]
ChEMBL Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand B 7.82 pKi 15 nM Ki J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
ChEMBL Displacement of [3H]-(+)-pentazocine from recombinant human sigma1 receptor expressed in HEK293 cell membranes after 120 mins by microbeta scintillation counting method B 7.82 pKi 15 nM Ki Bioorg Med Chem (2019) 27: 1824-1835 [PMID:30904383]
ChEMBL Binding affinity to sigma 1 receptor (unknown origin) B 7.82 pKi 15 nM Ki J Med Chem (2016) 59: 6329-6343 [PMID:27309376]
ChEMBL Inhibition of specific binding of [3H]3-PPP to sigma binding site in Guinea pig brain membranes B 7.28 pIC50 53 nM IC50 J Med Chem (1992) 35: 4683-4689 [PMID:1469697]
ChEMBL In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates B 7.42 pIC50 38 nM IC50 J Med Chem (1990) 33: 2421-2429 [PMID:1975275]
ChEMBL In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates B 7.49 pIC50 32 nM IC50 J Med Chem (1990) 33: 2421-2429 [PMID:1975275]
ChEMBL The compound was evaluated for binding affinity against sigma opioid receptor using [3H]DTG radioligand in guinea pig membranes B 7.49 pIC50 32 nM IC50 Bioorg Med Chem Lett (1993) 3: 2113-2116
ChEMBL Tested in vitro for the concentration required to inhibit specific [3H]DTG radioligand binding to sigma receptor on guinea pig brain membrane B 7.51 pIC50 31 nM IC50 J Med Chem (1994) 37: 260-267 [PMID:8295213]
ChEMBL Displacement of [3H]DTG from sigma opioid receptor of homogenized guinea pig whole brain B 7.55 pIC50 28 nM IC50 J Med Chem (1991) 34: 1867-1870 [PMID:1648140]
ChEMBL Inhibition of specific binding of [3H]DTG to sigma binding site in Guinea pig brain membranes B 7.55 pIC50 28 nM IC50 J Med Chem (1992) 35: 4683-4689 [PMID:1469697]
ChEMBL Inhibition of specific binding of [125I]-PIPAG to sigma binding site in Guinea pig brain membranes B 7.74 pIC50 18 nM IC50 J Med Chem (1992) 35: 4683-4689 [PMID:1469697]
ChEMBL Inhibition of specific binding of [3H]NANM of sigma binding site in Guinea pig brain membranes B 7.82 pIC50 15 nM IC50 J Med Chem (1992) 35: 4683-4689 [PMID:1469697]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
ChEMBL Displacement of [3H](+)-pentazocine from sigma 1 receptor in rat liver membrane B 6.74 pKi 180 nM Ki Eur J Med Chem (2009) 44: 124-130 [PMID:18440098]
ChEMBL Displacement of [3H](+)-pentazocine from sigma1 receptor in rat liver membrane by liquid scintillation counting B 6.74 pKi 180 nM Ki J Med Chem (2009) 52: 5380-5393 [PMID:19673530]
ChEMBL Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting B 6.88 pKi 131.1 nM Ki Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]
ChEMBL Binding affinity to sigma 1 receptor in rat C6 cells B 7.05 pKi 88.5 nM Ki J Med Chem (2009) 52: 7817-7828 [PMID:19842660]
ChEMBL Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand B 7.19 pKi 63.9 nM Ki J Med Chem (2002) 45: 438-448 [PMID:11784148]
ChEMBL Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes B 6.4 pIC50 400 nM IC50 J Med Chem (2000) 43: 177-189 [PMID:10649973]
ChEMBL Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand B 7.28 pIC50 52 nM IC50 J Med Chem (1995) 38: 2009-2017 [PMID:7783132]
ChEMBL Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. B 7.44 pIC50 36 nM IC50 J Med Chem (1995) 38: 2009-2017 [PMID:7783132]
ChEMBL Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine B 7.44 pIC50 36 nM IC50 J Med Chem (1995) 38: 1998-2008 [PMID:7783131]
Vesicular acetylcholine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
ChEMBL Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting B 5.95 pKi 1134 nM Ki Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]