SM 21 [Ligand Id: 6682] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL45951
  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL Binding affinity to sigma-1 opioid receptor (unknown origin) B 6 pKi >1000 nM Ki J. Med. Chem. (2013) 56: 7137-7160 [PMID:23734634]
σ2 in Human [GtoPdb: 2553] [UniProtKB: Q5BJF2]
GtoPdb - - 7.2 pIC50 - - - Life Sci. (1999) 64: PL131-7 [PMID:10096443]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]