icatibant [Ligand Id: 667] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2028850 (HOE-140, Icatibant)
  • B2 receptor/Bradykinin B2 receptor in Human [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
  • B2 receptor in Mouse [GtoPdb: 42] [UniProtKB: P32299]
  • B2 receptor/Bradykinin B2 receptor in Rat [ChEMBL: CHEMBL2501] [GtoPdb: 42] [UniProtKB: P25023]
  • Bradykinin B2 receptor in Guinea pig [ChEMBL: CHEMBL4111] [UniProtKB: O70526]
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  • B1 receptor in Human [GtoPdb: 41] [UniProtKB: P46663]
  • B1 receptor in Rat [GtoPdb: 41] [UniProtKB: P97583]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
ChEMBL Antagonist effect against bradykinin B2 receptor was determined in rabbit jugular vein F 9.04 pKd 0.91 nM Kd Bioorg. Med. Chem. Lett. (1994) 4: 781-784
ChEMBL Antagonist activity against bradykinin B2 receptor F 9.55 pKd 0.28 nM Kd Bioorg. Med. Chem. Lett. (2006) 16: 2387-2390 [PMID:16504505]
ChEMBL Binding affinity towards Bradykinin receptor B2 in human S34 clone cells B 9.74 pKi 0.18 nM Ki J. Med. Chem. (1996) 39: 1472-1484 [PMID:8691478]
GtoPdb - - 10.19 pKi 0.06 nM Ki J Med Chem (1999) 42: 4185-92 [PMID:10514288]
ChEMBL Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand B 10.19 pKi 0.06 nM Ki J. Med. Chem. (1999) 42: 4185-4192 [PMID:10514288]
ChEMBL Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement. B 10.22 pKi 0.06 nM Ki J. Med. Chem. (1999) 42: 4193-4201 [PMID:10514289]
ChEMBL Binding affinity to human bradykinin B2 receptor transfected in CHO cells B 10.6 pKi 0.03 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2387-2390 [PMID:16504505]
ChEMBL Concentration required to inhibit specific binding of [3H]BK (1.2 nM) to A-431 cells (human epidermoid carcinoma) which express Bradykinin receptor B2 by 50%. B 8.48 pIC50 3.3 nM IC50 J. Med. Chem. (1998) 41: 4062-4079 [PMID:9767643]
ChEMBL Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoid carcinoma) which express Bradykinin receptor B2 by 50%. B 8.48 pIC50 3.3 nM IC50 J. Med. Chem. (1998) 41: 4053-4061 [PMID:9767642]
ChEMBL Inhibition specific binding of [3H]BK (1.0 nM) to human Bradykinin receptor B2 which was expressed in CHO (Chinese hamster ovary) cells by 50%. B 9.31 pIC50 0.49 nM IC50 J. Med. Chem. (1998) 41: 4062-4079 [PMID:9767643]
ChEMBL In vitro inhibitory activity towards human bradykinin receptor B2 expressed in CHO cells using [3H]BK (1.0 nM) as a radioligand B 9.31 pIC50 0.49 nM IC50 J. Med. Chem. (2004) 47: 1617-1630 [PMID:15027853]
GtoPdb - - 9.4 pIC50 - - - Mol Pharmacol (1994) 45: 1-8 [PMID:8302267];
Mol Pharmacol (1997) 51: 171-6 [PMID:9203620]
GtoPdb - - 8.4 pA2 - - - Br J Pharmacol (1996) 118: 289-94 [PMID:8735629]
B2 receptor in Mouse [GtoPdb: 42] [UniProtKB: P32299]
GtoPdb - - 9.6 pKi - - - Mol Pharmacol (1994) 45: 1-8 [PMID:8302267]
B2 receptor/Bradykinin B2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2501] [GtoPdb: 42] [UniProtKB: P25023]
ChEMBL In vitro Bradykinin receptor B2 antagonist activity by using rat uterus functional assay F 9.5 pKd 0.32 nM Kd J. Med. Chem. (1996) 39: 1472-1484 [PMID:8691478]
ChEMBL Binding affinity against rat bradykinin B2 receptors expressed in CHO cells using [3H]bradykinin as radioligand B 10.11 pKi 0.08 nM Ki J. Med. Chem. (1999) 42: 4185-4192 [PMID:10514288]
GtoPdb - - 10.3 pKi - - - Br J Pharmacol (2000) 129: 77-86 [PMID:10694205]
Bradykinin B2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4111] [UniProtKB: O70526]
ChEMBL In vitro binding affinity against bradykinin receptor B2 from guinea pig ileum. B 9.96 pKi 0.11 nM Ki J. Med. Chem. (1993) 36: 1450-1460 [PMID:8388469]
ChEMBL In vitro antagonistic activity for Bradykinin receptor B2 by guinea pig pulmonary artery assay. F 8.27 pIC50 5.4 nM IC50 J. Med. Chem. (1995) 38: 2799-2801 [PMID:7636840]
ChEMBL In vitro antagonistic activity for Bradykinin receptor B2 by guinea pig ileal membrane receptor assay. F 8.97 pIC50 1.07 nM IC50 J. Med. Chem. (1995) 38: 2799-2801 [PMID:7636840]
ChEMBL Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%. B 10.05 pIC50 0.09 nM IC50 J. Med. Chem. (1998) 41: 4062-4079 [PMID:9767643]
ChEMBL Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%. B 10.05 pIC50 0.09 nM IC50 J. Med. Chem. (1998) 41: 4053-4061 [PMID:9767642]
ChEMBL In vitro inhibitory activity towards bradykinin receptor B2 using [3H]BK (0.06 nM) as a radioligand in guinea pig ileum membrane preparation B 10.05 pIC50 0.09 nM IC50 J. Med. Chem. (2004) 47: 1617-1630 [PMID:15027853]
B1 receptor in Human [GtoPdb: 41] [UniProtKB: P46663]
GtoPdb - - 7 pKi - - - Eur J Pharmacol (1999) 374: 423-433 [PMID:10422787];
Br J Pharmacol (1997) 122: 393-9 [PMID:9313952]
B1 receptor in Rat [GtoPdb: 41] [UniProtKB: P97583]
GtoPdb - - 6.4 pKi - - - Eur J Pharmacol (1999) 374: 423-433 [PMID:10422787]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]