myriocin [Ligand Id: 6664] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL55076 (Myriocin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| serine palmitoyltransferase long chain base subunit 1/Serine palmitoyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250343] [GtoPdb: 2509] [UniProtKB: O15269] | ||||||||
| ChEMBL | Inhibition of SPT1 in human MCF7 cells assessed as suppression of 14C-serine incorporation into ceramide incubated for 2 hrs in presence of 4-HPR | B | 7.31 | pEC50 | 49.5 | nM | EC50 | J Med Chem (2016) 59: 5904-5910 [PMID:27213958] |
| serine palmitoyltransferase long chain base subunit 1 in Mouse [GtoPdb: 2509] [UniProtKB: O35704] | ||||||||
| GtoPdb | - | - | 9.55 | pKi | 0.28 | nM | Ki | Biochem Biophys Res Commun (1995) 211: 396-403 [PMID:7794249] |
| serine palmitoyltransferase long chain base subunit 2/Serine palmitoyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250344] [GtoPdb: 2510] [UniProtKB: O15270] | ||||||||
| ChEMBL | Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substrate addition measured after 15 mins by mass spectrometric analysis | B | 9.89 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem (2018) 26: 2452-2465 [PMID:29669694] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
