ChEMBL ligand: CHEMBL279390 (Lazabemide, RO-196327, RO 19-6327/000)
Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] Monoamine oxidase A in Rat [ChEMBL: CHEMBL3358] [UniProtKB: P21396] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] Monoamine oxidase B in Rat [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL	Inhibition of MAOA (unknown origin) using kynuramine as substrate preincubated for 30 mins followed by substrate addition	B	4.1	pIC50	>80000	nM	IC50	Medchemcomm (2018) 9: 1871-1881 [PMID:30568755]
Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396]
ChEMBL	In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (1994) 4: 1195-1198
ChEMBL	In vitro inhibitory activity against rat brain Monoamine oxidase A	B	5	pIC50	>10000	nM	IC50	J Med Chem (1995) 38: 4786-4792 [PMID:7490728]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL	Binding affinity to human recombinant microsomal MAO-B by ITC	B	7.18	pKd	66	nM	Kd	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition constant against human recombinant Monoamine oxidase-B	B	7.08	pKi	84	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4438-4446 [PMID:16137882]
GtoPdb	-	-	7.08	pKi	84	nM	Ki	Adv Neurol (1990) 53: 505-12 [PMID:2122653]; Bioorg Med Chem Lett (2005) 15: 4438-46 [PMID:16137882]
ChEMBL	Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins by MAO-Glo assay	B	7.14	pKi	72.2	nM	Ki	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition of recombinant human MAO-B assessed as reduction in H2O2 production preincubated for 30 mins followed by p-tyramine substrate addition measured after 30 mins by amplex red reagent based fluorescence assay	B	8.22	pKi	6	nM	Ki	Medchemcomm (2018) 9: 1164-1171 [PMID:30109004]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Amplex red reagent based fluorescence analysis	B	8.3	pKi	5	nM	Ki	J Med Chem (2021) 64: 1989-2009 [PMID:33533632]
ChEMBL	Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins by MAO-Glo assay	B	8.41	pKi	3.9	nM	Ki	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for 30 mins followed by substrate addition	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1136-1140 [PMID:28188065]
ChEMBL	Inhibition of human recombinant monoamine oxidase-B assessed as kynuramine conversion to 6-hydroxyquinoline after 20 mins by fluorescence spectrophotometric analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1269-1273 [PMID:23374869]
ChEMBL	Reversible inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2013) 23: 5498-5502 [PMID:24012182]
ChEMBL	Inhibition of recombinant human MAO-B using kynuramine as substrate assessed as 4-hydroxyquinoline production after 30 mins by fluorescence spectrophotometry analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2758-2763 [PMID:24794105]
ChEMBL	Inhibition of recombinant human MAO-B expressed in insect cells assessed as inhibition of oxidation of kynuramine to 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Eur J Med Chem (2014) 82: 164-171 [PMID:24904963]
ChEMBL	Inhibition of human recombinant MAO-B assessed as kynuramine oxidation to 4-hydroxyquinoline formation by spectrofluorometric analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1206-1211 [PMID:25701250]
ChEMBL	Inhibition of human recombinant MAOB using kynuramine substrate assessed as reduction in MAO-generated 4-hydroxyquinoline level by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1896-1900 [PMID:25857942]
ChEMBL	Inhibition of human MAO-B expressed in baculovirus infected BT1 cells microsome fraction by fluorescence spectrometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5270-5276 [PMID:26432037]
ChEMBL	Inhibition of recombinant human MAO-B after 20 mins using 50 uM kynuramine as substrate by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1200-1204 [PMID:26821818]
ChEMBL	Inhibition of human recombinant MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometric analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2016) 26: 2214-2219 [PMID:27020523]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectroscopy	B	7.04	pIC50	91	nM	IC50	Eur J Med Chem (2017) 135: 196-203 [PMID:28456030]
ChEMBL	Inhibition of human recombinant MAO-B expressed in insect cell microsome assessed as 4-hydroxyquinoline formation using kynuramine as substrate after 20 mins by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem (2012) 20: 7040-7050 [PMID:23122934]
ChEMBL	Inhibition of recombinant human MAO-B using kynuramine as substrate after 20 mins by fluorescence spectrophotometric analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem (2018) 26: 5531-5537 [PMID:30279044]
ChEMBL	Inhibition of human recombinant MAO-B expressed in insect cells microsomes assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometry analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126677-126677 [PMID:31537422]
ChEMBL	Inhibition of recombinant human MAOB expressed in insect cell microsomes using kynuramine as substrate measured after 20 mins by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2019) 29: 40-46 [PMID:30455149]
ChEMBL	Inhibition of MAOB (unknown origin) using benzylamine as substrate preincubated for 30 mins followed by substrate addition	B	7.38	pIC50	42	nM	IC50	Medchemcomm (2018) 9: 1871-1881 [PMID:30568755]
ChEMBL	Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric method	B	7.43	pIC50	37	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
ChEMBL	Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophotometric analysis	B	7.48	pIC50	33	nM	IC50	Bioorg Med Chem Lett (2019) 29: 839-843 [PMID:30686752]
ChEMBL	Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate addition	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2018) 28: 584-588 [PMID:29395970]
ChEMBL	Inhibition of human recombinant soluble MAO-B assessed as thermal shift after 20 mins by SYPRO orange staining-based fluorescence assay	B	5.15	pEC50	7100	nM	EC50	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
Monoamine oxidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643]
ChEMBL	In vitro inhibitory activity against rat brain Monoamine oxidase B	B	7.52	pIC50	30	nM	IC50	J Med Chem (1995) 38: 4786-4792 [PMID:7490728]
ChEMBL	In vitro inhibitory activity against monoamine oxidase B (MAO-B) in rat brain homogenate.	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem Lett (1994) 4: 1195-1198

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]