4-hydroxyphenylpyruvic acid [Ligand Id: 6629] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL607712 (4-Hydroxyphenylpyruvate, 4-Hydroxy-Phenylpyruvate)
  • OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.18 pKi 66069.34 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.18 pKi 66000 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69]
ChEMBL Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr B 4.14 pKi 73000 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL Inhibition of mouse Oat1 expressed in Xenopus oocytes assessed as inhibition 6-carboxyfluorescein uptake after 1 hr by fluorometric analysis B 4.14 pKi 73000 nM Ki Bioorg. Med. Chem. (2011) 19: 3320-3340 [PMID:21571536]
ChEMBL Inhibition of mouse Oat1 expressed in Xenopus oocytes B 4.14 pKi 73000 nM Ki Bioorg. Med. Chem. (2011) 19: 3320-3340 [PMID:21571536]
ChEMBL Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr B 4.14 pKi 72443.6 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]