NVP-SAA164 [Ligand Id: 659] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL273869 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B1 bradykinin receptor in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250405] [UniProtKB: Q8HZP2] | ||||||||
| ChEMBL | Binding affinity to monkey bradykinin B1 receptor | B | 8.11 | pKi | 7.7 | nM | Ki | J Med Chem (2010) 53: 5383-5399 [PMID:20369879] |
| B1 receptor/Bradykinin B1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663] | ||||||||
| ChEMBL | Binding affinity for Bradykinin receptor B1 expressed in HEK293 cells | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2004) 47: 4642-4644 [PMID:15341478] |
| ChEMBL | Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (2010) 53: 5383-5399 [PMID:20369879] |
| GtoPdb | - | - | 8.1 | pKi | - | - | - |
Br J Pharmacol (2005) 144: 889-99 [PMID:15685199]; J Med Chem (2004) 47: 4642-4 [PMID:15341478] |
| ChEMBL | Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation | F | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2010) 53: 5383-5399 [PMID:20369879] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
