GR 144053 [Ligand Id: 6587] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL36326 (GR-144053, GR-144053F) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514] | ||||||||
| ChEMBL | Inhibition of glycoprotein IIb/III and platelet aggregation in human platelet rich plasma | F | 7.23 | pIC50 | 59 | nM | IC50 | J Med Chem (2000) 43: 3453-3473 [PMID:10999999] |
| ChEMBL | Inhibition of fibrinogen binding to platelet glycoprotein alpha IIb beta-3 integrin in ELISA | B | 8.1 | pIC50 | 7.94 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1531-1536 [PMID:9873384] |
| integrin αIIbβ3 in Human [GtoPdb: 2579] | ||||||||
| GtoPdb | Inhibition of ADP (10 µM)-induced aggregation in human gel-filtered platelets. | - | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (1994) 37: 3882-5 [PMID:7966149] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
