JMV1431 [Ligand Id: 656] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL408846 (JMV 1431)
  • B1 receptor/Bradykinin B1 receptor in Human [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663]
  • 7.09
1 CHEMBL408846_lig_chart_1 Bradykinin B1 receptor Human
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  • B2 receptor/Bradykinin B2 receptor in Human [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
  • 8.38
2 CHEMBL408846_lig_chart_2 Bradykinin B2 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
B1 receptor/Bradykinin B1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663]
ChEMBL Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin. B 7.08 pKi 83 nM Ki J. Med. Chem. (2000) 43: 2382-2386 [PMID:10882364]
GtoPdb - - 7.1 pKi - - - J Med Chem (2000) 43: 2382-6 [PMID:10882364]
B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
ChEMBL Ability to bind to human cloned B2 receptor in competition binding experiments with [3H]- bradykinin B 8.36 pKi 4.4 nM Ki J. Med. Chem. (2000) 43: 2382-2386 [PMID:10882364]
GtoPdb - - 8.4 pKi - - - J Med Chem (2000) 43: 2382-6 [PMID:10882364]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]