compound 18 [PMID: 15664838] [Ligand Id: 6536] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL367368
  • Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4]
Created with Highcharts 10.3.3ValuesChart context menuDipeptidyl peptidase IIpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
Created with Highcharts 10.3.3ValuesChart context menuDipeptidyl peptidase IVpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
Created with Highcharts 10.3.3ValuesChart context menuDipeptidyl peptidase VIIIpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4]
ChEMBL Inhibitory concentration against dipeptidylpeptidase 2 B 4.42 pIC50 38377 nM IC50 Bioorg Med Chem Lett (2005) 15: 687-691 [PMID:15664838]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibitory concentration against dipeptidylpeptidase IV B 4 pIC50 >100000 nM IC50 Bioorg Med Chem Lett (2005) 15: 687-691 [PMID:15664838]
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
ChEMBL Inhibitory concentration against dipeptidylpeptidase 8 B 7.85 pIC50 14 nM IC50 Bioorg Med Chem Lett (2005) 15: 687-691 [PMID:15664838]
GtoPdb - - 7.9 pIC50 14 nM IC50 Bioorg Med Chem Lett (2005) 15: 687-91 [PMID:15664838]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]