Z-Arg-Leu-Val-Agly-Ile-Val-OMe [Ligand Id: 6534] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2028907
Created with Highcharts 10.3.3ValuesChart context menuCathepsin BpKd HumanpKi HumanpIC50 HumanpEC50 Human024681012Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCathepsin KpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuPapainpKd Carica papayapKi Carica papayapIC50 Carica papayapEC50 Carica papaya0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858]
ChEMBL Inhibition of Human Cathepsin B B 10.06 pKi 0.09 nM Ki J Med Chem (2002) 45: 4202-4211 [PMID:12213061]
GtoPdb - - 10.1 pKi 0.09 nM Ki J Med Chem (2002) 45: 4202-11 [PMID:12213061]
cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235]
ChEMBL Inhibition of Human Cathepsin K B 7.68 pKi 21 nM Ki J Med Chem (2002) 45: 4202-4211 [PMID:12213061]
Papain in Carica papaya (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4779] [UniProtKB: P00784]
ChEMBL In vitro inhibition of papain. B 9.11 pKi 0.77 nM Ki J Med Chem (2002) 45: 4202-4211 [PMID:12213061]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]