triazine compound PC7 [Ligand Id: 6431] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL550577 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PKR1/Prokineticin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5649] [GtoPdb: 335] [UniProtKB: Q8TCW9] | ||||||||
| GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 |
Bioorg Med Chem Lett (2009) 19: 2661-3 [PMID:19375913]; J Nucl Med (2011) 52: 600-7 [PMID:21421710] |
| ChEMBL | Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay | F | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2661-2663 [PMID:19375913] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
