Ro4491533 [Ligand Id: 6226] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1629855 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu2 receptor in Human [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| GtoPdb | - | - | 8.21 | pKi | 6.2 | nM | Ki | J Neurogenet (2011) 25: 152-66 [PMID:22091727] |
| GtoPdb | - | - | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6969-74 [PMID:20971004] |
| mGlu2 receptor in Rat [GtoPdb: 290] [UniProtKB: P31421] | ||||||||
| GtoPdb | - | - | 8.27 | pKi | 5.4 | nM | Ki | J Neurogenet (2011) 25: 152-66 [PMID:22091727] |
| GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 |
Bioorg Med Chem Lett (2010) 20: 6969-74 [PMID:20971004]; J Neurogenet (2011) 25: 152-66 [PMID:22091727] |
| mGlu3 receptor in Human [GtoPdb: 291] [UniProtKB: Q14832] | ||||||||
| GtoPdb | - | - | 6.6 | pIC50 | 270 | nM | IC50 | J Neurogenet (2011) 25: 152-66 [PMID:22091727] |
| mGlu3 receptor in Rat [GtoPdb: 291] [UniProtKB: P31422] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | <10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6969-74 [PMID:20971004] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
