MK-5046 [Ligand Id: 6170] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1672354 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BB1 receptor in Human [GtoPdb: 38] [UniProtKB: P28336] | ||||||||
| GtoPdb | - | - | 5 | pIC50 | >10000 | nM | IC50 |
Pharmacol Exp Therap (2013) 347: 100-116 [PMID:23892571]; J Pharmacol Exp Ther (2011) 336: 356-64 [PMID:21036912] |
| BB2 receptor in Human [GtoPdb: 39] [UniProtKB: P30550] | ||||||||
| GtoPdb | - | - | 5 | pIC50 | >10000 | nM | IC50 | Pharmacol Exp Therap (2013) 347: 100-116 [PMID:23892571] |
| BB3 receptor in Human [GtoPdb: 40] [UniProtKB: P32247] | ||||||||
| GtoPdb | - | - | 8.43 | pKi | - | - | - |
Pharmacol Exp Therap (2013) 347: 100-116 [PMID:23892571]; ACS Med Chem Lett (2011) 2: 43-7 [PMID:24900253] |
| GtoPdb | - | - | 7.57 | pIC50 | 27 | nM | IC50 |
Pharmacol Exp Therap (2013) 347: 100-116 [PMID:23892571]; ACS Med Chem Lett (2011) 2: 43-7 [PMID:24900253] |
| GtoPdb | - | - | 7.6 | pEC50 | 25 | nM | EC50 | ACS Med Chem Lett (2011) 2: 43-7 [PMID:24900253] |
| BB3 receptor in Mouse [GtoPdb: 40] [UniProtKB: O54798] | ||||||||
| GtoPdb | - | - | 8.8 | pKi | 1.6 | nM | Ki | J Pharmacol Exp Ther (2011) 336: 356-64 [PMID:21036912] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
