PKR inhibitor [Ligand Id: 6026] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL235641
  • mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
Created with Highcharts 10.3.3ValuesChart context menuMitogen-activated protein kinase kinase kinase 11pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase NEK6pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase NEK7pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • eukaryotic translation initiation factor 2 alpha kinase 2 in Human [GtoPdb: 2016] [UniProtKB: P19525]
Created with Highcharts 10.3.3ValuesChart context menueukaryotic translation initiation factor 2 alpha kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
ChEMBL Inhibition of human MLK3 by ATP-competitive binding assay B 6.84 pIC50 144 nM IC50 Bioorg Med Chem Lett (2024) 101: 129652-129652 [PMID:38346577]
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
ChEMBL Inhibition of human NEK6 using casein as substrate by [gamma-33P]-ATP assay B 4.22 pIC50 59800 nM IC50 Eur J Med Chem (2019) 161: 456-467 [PMID:30384048]
NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
ChEMBL Inhibition of human NEK7 using casein as substrate by [gamma-33P]-ATP assay B 5.14 pIC50 7280 nM IC50 Eur J Med Chem (2019) 161: 456-467 [PMID:30384048]
eukaryotic translation initiation factor 2 alpha kinase 2 in Human [GtoPdb: 2016] [UniProtKB: P19525]
GtoPdb - - 6.68 pIC50 210 nM IC50 Biochem Biophys Res Commun (2003) 308: 50-7 [PMID:12890478]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]