MEK inhibitor I [Ligand Id: 6006] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL37493 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| GtoPdb | - | - | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1483-6 [PMID:15006386] |
| ChEMBL | Inhibitory potency against mitogen activated protein kinase kinase 1 | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1483-1486 [PMID:15006386] |
| mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734] | ||||||||
| GtoPdb | - | - | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1483-6 [PMID:15006386] |
| ChEMBL | Inhibitory potency against MAP kinase kinase 3 (MKK3) | F | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1483-1486 [PMID:15006386] |
| mitogen-activated protein kinase kinase 4 in Human [GtoPdb: 2065] [UniProtKB: P45985] | ||||||||
| GtoPdb | - | - | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1483-6 [PMID:15006386] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
