KN-93 [Ligand Id: 6002] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL155333 (KN-93) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cAMP-dependent protein kinase A in Bovine (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111446] [UniProtKB: P00515, P00517, P05131, P31322] | ||||||||
| ChEMBL | Inhibition of Protein kinase A (PKA) activity, Enzyme assay was done using gamma-[32P]ATP and synthetic peptide substrates | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2002) 45: 563-566 [PMID:11806708] |
| Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799] | ||||||||
| ChEMBL | Inhibition of Myosin Light Chain kinase (MLCK) | B | 5.01 | pIC50 | 9800 | nM | IC50 | J Med Chem (2002) 45: 563-566 [PMID:11806708] |
| calcium/calmodulin-dependent protein kinase II alpha subunit in Mouse [GtoPdb: 1555] [UniProtKB: P11798] | ||||||||
| GtoPdb | Assayed using purified mouse CaMKiiα subunit (Komiya et al, 2011). | - | 6.43 | pIC50 | 370 | nM | IC50 |
Bioorg Med Chem Lett (2011) 21: 1456-8 [PMID:21292482]; Biochem Biophys Res Commun (1991) 181: 968-75 [PMID:1662507] |
| calcium/calmodulin-dependent protein kinase II alpha subunit in Rat [GtoPdb: 1555] [UniProtKB: P11275] | ||||||||
| GtoPdb | Assay performed using a truncated, recombinant rat CAMKIIalpha subunit, expressed in and purified from Sf9 cells. | - | 5.08 | pIC50 | 8400 | nM | IC50 | J Med Chem (2002) 31: 563-6 [PMID:11806708] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
