zolmitriptan [Ligand Id: 60] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1185 (311-C-90, 311C90, Cvt-427, NSC-760383, Zolmitriptan, Zomig, Zomig-zmt) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand | B | 9.52 | pKd | 0.3 | nM | Kd | J Med Chem (1995) 38: 3566-3580 [PMID:7658443] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Binding affinity against Dopamine receptor D2 in rat striatum using [3H]-spiperone as radioligand | B | 10.4 | pKd | 0.04 | nM | Kd | J Med Chem (1995) 38: 3566-3580 [PMID:7658443] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1 receptor using rabbit jugular vein assay in the absence of endothelium | B | 8.74 | pKd | 1.8 | nM | Kd | J Med Chem (1995) 38: 3566-3580 [PMID:7658443] |
| GtoPdb | - | - | 6.6 | pKi | - | - | - | Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663] |
| ChEMBL | In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT radioligand | B | 6.91 | pKi | 124 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 675-680 [PMID:9871581] |
| ChEMBL | Binding affinity for cloned human 5-hydroxytryptamine 1A receptor | B | 7.1 | pKi | 78.6 | nM | Ki | J Med Chem (1995) 38: 3602-3607 [PMID:7658447] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay. | B | 8.82 | pKd | 1.5 | nM | Kd | J Med Chem (1995) 38: 3566-3580 [PMID:7658443] |
| GtoPdb | - | - | 7.7 | pKi | - | - | - | Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663] |
| ChEMBL | In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1B receptor using [3H]5-CT radioligand | B | 8.38 | pKi | 4.2 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 675-680 [PMID:9871581] |
| ChEMBL | Binding affinity to 5-HT1B receptor (unknown origin) assessed as inhibition constant | B | 9.4 | pKi | 0.4 | nM | Ki | RSC Med Chem (2024) 15: 788-808 [PMID:38516587] |
| ChEMBL | Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor | B | 8.21 | pIC50 | 6.17 | nM | IC50 | J Med Chem (2001) 44: 681-693 [PMID:11262079] |
| ChEMBL | Effective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfected in CHO cell lines | F | 7.8 | pEC50 | 15.7 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 675-680 [PMID:9871581] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay. | B | 8.82 | pKd | 1.5 | nM | Kd | J Med Chem (1995) 38: 3566-3580 [PMID:7658443] |
| ChEMBL | Binding affinity for cloned human 5-hydroxytryptamine 1D receptor beta | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (1995) 38: 3602-3607 [PMID:7658447] |
| GtoPdb | - | - | 8.9 | pKi | - | - | - | Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663] |
| ChEMBL | Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha | B | 9.04 | pKi | 0.92 | nM | Ki | J Med Chem (1995) 38: 3602-3607 [PMID:7658447] |
| ChEMBL | In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand | B | 9.12 | pKi | 0.76 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 675-680 [PMID:9871581] |
| ChEMBL | Binding affinity to 5-HT1DR (unknown origin) assessed as inhibition constant | B | 9.4 | pKi | 0.4 | nM | Ki | RSC Med Chem (2024) 15: 788-808 [PMID:38516587] |
| ChEMBL | Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor | B | 8.55 | pIC50 | 2.82 | nM | IC50 | J Med Chem (2001) 44: 681-693 [PMID:11262079] |
| 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
| GtoPdb | - | - | 7.7 | pKi | - | - | - | Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663] |
| 5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939] | ||||||||
| GtoPdb | - | - | 7.5 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510]; Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
