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ChEMBL ligand: CHEMBL596674 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Protein-glutamine gamma-glutamyltransferase in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308976] [UniProtKB: Q7M0F8] | ||||||||
ChEMBL | Inhibition of guinea pig liver transglutaminase | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1141-1144 [PMID:20053561] |
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] | ||||||||
ChEMBL | MERS_3CL Pro protease inhibition IC50 by FRET kind of response from peptide substrate | F | 5.09 | pIC50 | 8100 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] | ||||||||
ChEMBL | SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate | F | 6.24 | pIC50 | 580 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 (unknown origin) by ELISA | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4229-4237 [PMID:28844493] |
GtoPdb | - | - | 7.1 | pIC50 | 79 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 575-9 [PMID:10741557] |
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
GtoPdb | - | - | 4.4 | pIC50 | 39810 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 575-9 [PMID:10741557] |
transglutaminase 2 in Human [GtoPdb: 3015] [UniProtKB: P21980] | ||||||||
GtoPdb | In the absence of DTT. | - | 8 | pIC50 | 10 | nM | IC50 | Chem Biol (2008) 15: 969-78 [PMID:18804034] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]