IRAK-1/4 inhibitor [Ligand Id: 5990] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL379787
  • interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
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  • interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
GtoPdb - - 6.52 pIC50 300 nM IC50 Bioorg Med Chem Lett (2006) 16: 2842-5 [PMID:16563752]
ChEMBL Inhibition of IRAK1 B 6.52 pIC50 300 nM IC50 Bioorg Med Chem Lett (2006) 16: 2842-2845 [PMID:16563752]
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
ChEMBL Inhibition of IRAK4 B 6.7 pIC50 200 nM IC50 Bioorg Med Chem Lett (2006) 16: 2842-2845 [PMID:16563752]
GtoPdb - - 6.7 pIC50 200 nM IC50 Bioorg Med Chem Lett (2006) 16: 2842-5 [PMID:16563752]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]