GSK-3 inhibitor IX [Ligand Id: 5974] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2178734
  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
  • This target only has 0 pki data point
  • 0
1 CHEMBL2178734_lig_chart_1 cyclin dependent kinase 1 Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
  • This target only has 0 pki data point
  • 0
2 CHEMBL2178734_lig_chart_2 cyclin dependent kinase 5 Human
There should be some charts here, you may need to enable JavaScript!
  • glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
  • This target only has 0 pki data point
  • 0
3 CHEMBL2178734_lig_chart_3 glycogen synthase kinase 3 alpha Pig
There should be some charts here, you may need to enable JavaScript!
  • glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
  • This target only has 0 pki data point
  • 0
4 CHEMBL2178734_lig_chart_4 glycogen synthase kinase 3 beta Pig
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb CDK1/cyclin B complex - 6.49 pIC50 320 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
GtoPdb CDK5/p25 complex - 7.08 pIC50 83 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
GtoPdb GSK3α/β complex from pig brain - 8.3 pIC50 5 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
GtoPdb GSK3α/β complex from pig brain - 8.3 pIC50 5 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]