GSK-3 inhibitor IX [Ligand Id: 5974] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2178734
  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
Created with Highcharts 10.3.3ValuesChart context menucyclin dependent kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
Created with Highcharts 10.3.3ValuesChart context menucyclin dependent kinase 5pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
Created with Highcharts 10.3.3ValuesChart context menuglycogen synthase kinase 3 alphapKd PigpKi PigpIC50 PigpEC50 Pig0246810Highcharts.com
  • glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
Created with Highcharts 10.3.3ValuesChart context menuglycogen synthase kinase 3 betapKd PigpKi PigpIC50 PigpEC50 Pig0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb CDK1/cyclin B complex - 6.49 pIC50 320 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
GtoPdb CDK5/p25 complex - 7.08 pIC50 83 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029]
GtoPdb GSK3α/β complex from pig brain - 8.3 pIC50 5 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]
glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030]
GtoPdb GSK3α/β complex from pig brain - 8.3 pIC50 5 nM IC50 J Med Chem (2004) 47: 935-46 [PMID:14761195];
Chem Biol (2003) 10: 1255-66 [PMID:14700633]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]