Flt-3 inhibitor [Ligand Id: 5970] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL210833 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of Flt3 activity in human MV 3:11 cells by phosphotyrosine cell-based ELISA | B | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (2010) 53: 1563-1578 [PMID:20092323] |
| ChEMBL | Inhibition of FLT3 | B | 7.38 | pIC50 | 42 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3282-3286 [PMID:16580199] |
| GtoPdb | - | - | 7.38 | pIC50 | 42 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3282-6 [PMID:16580199] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
