ERK inhibitor III [Ligand Id: 5968] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL221271
  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
  • This target only has 0 pki data point
  • 0
1 CHEMBL221271_lig_chart_1 MAP kinase ERK2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Binding affinity to ERK2 by fluorescence quenching B 4.89 pKd 13000 nM Kd Bioorg. Med. Chem. Lett. (2006) 16: 6281-6287 [PMID:17000106]
GtoPdb Measuring binding of the compound to human ERK2 in a fluorescence spectroscopy experiment, where fluorescence quenching is indicative of a binding interaction - 4.89 pKd 13000 nM Kd Bioorg Med Chem Lett (2006) 16: 6281-7 [PMID:17000106]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]