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ChEMBL ligand: CHEMBL104468 (LY-293646) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527] | ||||||||
ChEMBL | Inhibition of DNA-PK | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2011) 19: 3983-3994 [PMID:21664823] |
ChEMBL | Inhibition of DNA dependent protein kinase isolated from HeLa cells | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (2005) 48: 569-585 [PMID:15658870] |
ChEMBL | Inhibitory activity against DNA-dependent protein kinase (DNA-PK) | B | 6.64 | pIC50 | 230 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735] |
ChEMBL | Inhibitory activity against DNA-dependent protein kinase receptor | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (2005) 48: 7829-7846 [PMID:16302822] |
ChEMBL | Inhibition of DNA-PK | B | 6.64 | pIC50 | 230 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assay | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (2011) 54: 2320-2330 [PMID:21413798] |
ChEMBL | In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells. | B | 6.64 | pIC50 | 230 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3083-3086 [PMID:12941339] |
ChEMBL | Inhibition of DNA-PK purified from human HeLa nuclear extracts | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (2015) 58: 41-71 [PMID:25387153] |
GtoPdb | - | - | 6.64 | pIC50 | 230 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3083-6 [PMID:12941339] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
ChEMBL | Inhibition of Phosphatidylinositol 3-kinase | B | 4.89 | pIC50 | 13000 | nM | IC50 | J Med Chem (2005) 48: 569-585 [PMID:15658870] |
ChEMBL | Inhibition of Phosphatidylinositol 3-kinase p110 alpha subunit | B | 4.89 | pIC50 | 13000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735] |
ChEMBL | Inhibition of PI3K p110alpha (unknown origin) | B | 4.89 | pIC50 | 13000 | nM | IC50 | J Med Chem (2015) 58: 41-71 [PMID:25387153] |
phosphoinositide-3-kinase regulatory subunit 1/PI3-kinase p85-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2506] [GtoPdb: 2503] [UniProtKB: P27986] | ||||||||
ChEMBL | Inhibition of PI3K | B | 4.89 | pIC50 | 13000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ATM serine/threonine kinase/Serine-protein kinase ATM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3797] [GtoPdb: 1934] [UniProtKB: Q13315] | ||||||||
ChEMBL | Inhibition of ATM kinase using rabbit polyclonal antisera; No inhibition observed at 100 uM | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 569-585 [PMID:15658870] |
ChEMBL | Inhibition of Mutated in ataxia telangiectasia protein ATM kinase | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735] |
ChEMBL | Inhibition of ATM | B | 4 | pIC50 | >100000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2011) 54: 2320-2330 [PMID:21413798] |
ATR serine/threonine kinase/Serine-protein kinase ATR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535] | ||||||||
ChEMBL | Inhibition of ATR kinase using rabbit polyclonal antisera; No inhibition observed at 100 uM | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 569-585 [PMID:15658870] |
ChEMBL | Inhibition of Ataxia telangiectasia related protein ATR kinase | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735] |
ChEMBL | Inhibition of ATR | B | 4 | pIC50 | >100000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2011) 54: 2320-2330 [PMID:21413798] |
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
ChEMBL | Inhibition of mTOR protein isolated from HeLa cells | B | 5.19 | pIC50 | 6400 | nM | IC50 | J Med Chem (2005) 48: 569-585 [PMID:15658870] |
ChEMBL | Inhibition of Mammalian target of Rapamycin mTOR | B | 5.19 | pIC50 | 6400 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735] |
ChEMBL | Inhibition of mTOR by radiometric phosphate incorporation assay | B | 5.19 | pIC50 | 6400 | nM | IC50 | J Med Chem (2011) 54: 2320-2330 [PMID:21413798] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]