ChEMBL ligand: CHEMBL104468 (LY-293646)
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphoinositide-3-kinase regulatory subunit 1/PI3-kinase p85-alpha subunit in Human [ChEMBL: CHEMBL2506] [GtoPdb: 2503] [UniProtKB: P27986] There should be some charts here, you may need to enable JavaScript!
ATM serine/threonine kinase/Serine-protein kinase ATM in Human [ChEMBL: CHEMBL3797] [GtoPdb: 1934] [UniProtKB: Q13315] There should be some charts here, you may need to enable JavaScript!
ATR checkpoint kinase/Serine-protein kinase ATR in Human [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535] There should be some charts here, you may need to enable JavaScript!
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
ChEMBL	Inhibition of DNA-PK	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2011) 19: 3983-3994 [PMID:21664823]
ChEMBL	Inhibition of DNA dependent protein kinase isolated from HeLa cells	B	6.64	pIC50	230	nM	IC50	J Med Chem (2005) 48: 569-585 [PMID:15658870]
ChEMBL	Inhibitory activity against DNA-dependent protein kinase (DNA-PK)	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735]
ChEMBL	Inhibitory activity against DNA-dependent protein kinase receptor	B	6.64	pIC50	230	nM	IC50	J Med Chem (2005) 48: 7829-7846 [PMID:16302822]
ChEMBL	Inhibition of DNA-PK	B	6.64	pIC50	230	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL	Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assay	B	6.64	pIC50	230	nM	IC50	J Med Chem (2011) 54: 2320-2330 [PMID:21413798]
ChEMBL	In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells.	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3083-3086 [PMID:12941339]
ChEMBL	Inhibition of DNA-PK purified from human HeLa nuclear extracts	B	6.64	pIC50	230	nM	IC50	J Med Chem (2015) 58: 41-71 [PMID:25387153]
GtoPdb	-	-	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3083-6 [PMID:12941339]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL	Inhibition of Phosphatidylinositol 3-kinase	B	4.89	pIC50	13000	nM	IC50	J Med Chem (2005) 48: 569-585 [PMID:15658870]
ChEMBL	Inhibition of Phosphatidylinositol 3-kinase p110 alpha subunit	B	4.89	pIC50	13000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735]
ChEMBL	Inhibition of PI3K p110alpha (unknown origin)	B	4.89	pIC50	13000	nM	IC50	J Med Chem (2015) 58: 41-71 [PMID:25387153]
phosphoinositide-3-kinase regulatory subunit 1/PI3-kinase p85-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2506] [GtoPdb: 2503] [UniProtKB: P27986]
ChEMBL	Inhibition of PI3K	B	4.89	pIC50	13000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ATM serine/threonine kinase/Serine-protein kinase ATM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3797] [GtoPdb: 1934] [UniProtKB: Q13315]
ChEMBL	Inhibition of ATM kinase using rabbit polyclonal antisera; No inhibition observed at 100 uM	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 569-585 [PMID:15658870]
ChEMBL	Inhibition of Mutated in ataxia telangiectasia protein ATM kinase	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735]
ChEMBL	Inhibition of ATM	B	4	pIC50	>100000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL	Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2011) 54: 2320-2330 [PMID:21413798]
ATR checkpoint kinase/Serine-protein kinase ATR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535]
ChEMBL	Inhibition of ATR kinase using rabbit polyclonal antisera; No inhibition observed at 100 uM	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 569-585 [PMID:15658870]
ChEMBL	Inhibition of Ataxia telangiectasia related protein ATR kinase	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735]
ChEMBL	Inhibition of ATR	B	4	pIC50	>100000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL	Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2011) 54: 2320-2330 [PMID:21413798]
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
ChEMBL	Inhibition of mTOR protein isolated from HeLa cells	B	5.19	pIC50	6400	nM	IC50	J Med Chem (2005) 48: 569-585 [PMID:15658870]
ChEMBL	Inhibition of Mammalian target of Rapamycin mTOR	B	5.19	pIC50	6400	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6083-6087 [PMID:15546735]
ChEMBL	Inhibition of mTOR by radiometric phosphate incorporation assay	B	5.19	pIC50	6400	nM	IC50	J Med Chem (2011) 54: 2320-2330 [PMID:21413798]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]