bohemine [Ligand Id: 5938] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL83980 (Bohemine)
  • cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL Inhibition of Cyclin-dependent kinase 1 B 5.6 pIC50 2500 nM IC50 J Med Chem (2000) 43: 2506-2513 [PMID:10891109]
GtoPdb CDK1/cyclin B complexes purified from sf9 cells - 5.96 pIC50 1100 nM IC50 Leukemia (2002) 16: 299-305 [PMID:11896531]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
ChEMBL Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2002) 12: 3283-3286 [PMID:12392733]
GtoPdb CDK1/cyclin B complexes purified from sf9 cells - 5.96 pIC50 1100 nM IC50 Leukemia (2002) 16: 299-305 [PMID:11896531]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of Cyclin-dependent kinase 2 B 6.1 pIC50 800 nM IC50 J Med Chem (2000) 43: 2506-2513 [PMID:10891109]
GtoPdb CDK2/cyclin E complexes purified from sf9 cells. - 6.22 pIC50 600 nM IC50 Leukemia (2002) 16: 299-305 [PMID:11896531]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]