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ChEMBL ligand: CHEMBL83980 (Bohemine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibition of Cyclin-dependent kinase 1 | B | 5.6 | pIC50 | 2500 | nM | IC50 | J. Med. Chem. (2000) 43: 2506-2513 [PMID:10891109] |
GtoPdb | CDK1/cyclin B complexes purified from sf9 cells | - | 5.96 | pIC50 | 1100 | nM | IC50 | Leukemia (2002) 16: 299-305 [PMID:11896531] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
ChEMBL | Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg. Med. Chem. Lett. (2002) 12: 3283-3286 [PMID:12392733] |
GtoPdb | CDK1/cyclin B complexes purified from sf9 cells | - | 5.96 | pIC50 | 1100 | nM | IC50 | Leukemia (2002) 16: 299-305 [PMID:11896531] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of Cyclin-dependent kinase 2 | B | 6.1 | pIC50 | 800 | nM | IC50 | J. Med. Chem. (2000) 43: 2506-2513 [PMID:10891109] |
GtoPdb | CDK2/cyclin E complexes purified from sf9 cells. | - | 6.22 | pIC50 | 600 | nM | IC50 | Leukemia (2002) 16: 299-305 [PMID:11896531] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]