bohemine [Ligand Id: 5938] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL83980 (Bohemine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | Inhibition of Cyclin-dependent kinase 1 | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2000) 43: 2506-2513 [PMID:10891109] |
| GtoPdb | CDK1/cyclin B complexes purified from sf9 cells | - | 5.96 | pIC50 | 1100 | nM | IC50 | Leukemia (2002) 16: 299-305 [PMID:11896531] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 3283-3286 [PMID:12392733] |
| GtoPdb | CDK1/cyclin B complexes purified from sf9 cells | - | 5.96 | pIC50 | 1100 | nM | IC50 | Leukemia (2002) 16: 299-305 [PMID:11896531] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibition of Cyclin-dependent kinase 2 | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2000) 43: 2506-2513 [PMID:10891109] |
| GtoPdb | CDK2/cyclin E complexes purified from sf9 cells. | - | 6.22 | pIC50 | 600 | nM | IC50 | Leukemia (2002) 16: 299-305 [PMID:11896531] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
