bohemine [Ligand Id: 5938] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL83980 (Bohemine)
  • cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL Inhibition of Cyclin-dependent kinase 1 B 5.6 pIC50 2500 nM IC50 J. Med. Chem. (2000) 43: 2506-2513 [PMID:10891109]
GtoPdb CDK1/cyclin B complexes purified from sf9 cells - 5.96 pIC50 1100 nM IC50 Leukemia (2002) 16: 299-305 [PMID:11896531]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
ChEMBL Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 3283-3286 [PMID:12392733]
GtoPdb CDK1/cyclin B complexes purified from sf9 cells - 5.96 pIC50 1100 nM IC50 Leukemia (2002) 16: 299-305 [PMID:11896531]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of Cyclin-dependent kinase 2 B 6.1 pIC50 800 nM IC50 J. Med. Chem. (2000) 43: 2506-2513 [PMID:10891109]
GtoPdb CDK2/cyclin E complexes purified from sf9 cells. - 6.22 pIC50 600 nM IC50 Leukemia (2002) 16: 299-305 [PMID:11896531]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]