BAY 11-7082 [Ligand Id: 5934] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL403183 (BAY-11-7082)
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  • Nuclear factor NF-kappa-B p65 subunit in Human [ChEMBL: CHEMBL5533] [UniProtKB: Q04206]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Nuclear factor NF-kappa-B complex in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094258] [UniProtKB: P19838Q00653Q04206]
ChEMBL Inhibition of TNF-alpha-induced NF-kappaB activity in HEK293 cells after 6 hrs by luciferase reporter gene assay B 5.7 pIC50 2000 nM IC50 J. Nat. Prod. (2014) 77: 1644-1649 [PMID:24992702]
Nuclear factor NF-kappa-B p65 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5533] [UniProtKB: Q04206]
ChEMBL Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 329-335 [PMID:18024113]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]