aminopurvalanol A [Ligand Id: 5927] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL286721 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2000) 43: 1282-1292 [PMID:10753466] |
| GtoPdb | CDK1 in association with cyclin B | - | 7.48 | pIC50 | 33 | nM | IC50 | Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363] |
| ChEMBL | In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes | B | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2000) 43: 1282-1292 [PMID:10753466] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
| ChEMBL | Inhibition of human CDK2/cyclinA using histone H1 as substrate incubated for 30 mins in presence of gamma[32P]ATP by phosphoimaging analysis | B | 7.3 | pIC50 | <50 | nM | IC50 | Eur J Med Chem (2016) 112: 298-346 [PMID:26907156] |
| GtoPdb | CDK2 in association with cyclin E | - | 7.55 | pIC50 | 28 | nM | IC50 | Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363] |
| CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
| ChEMBL | Inhibition of CLK mediated SF3B1 activation in human SK-MEL-2 cells assessed as MDM2-pre mRNA exon skipping after 4 hrs by luciferase reporter gene assay relative to control | B | 4.92 | pEC50 | 12000 | nM | EC50 | Bioorg Med Chem Lett (2017) 27: 406-412 [PMID:28049589] |
| cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
| GtoPdb | CDK5 p35 | - | 7.7 | pIC50 | 20 | nM | IC50 | Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
