aminopurvalanol A [Ligand Id: 5927] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL286721
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  • CDC like kinase 1/Dual specificty protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
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  • cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
ChEMBL In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes B 7.46 pIC50 35 nM IC50 J Med Chem (2000) 43: 1282-1292 [PMID:10753466]
GtoPdb CDK1 in association with cyclin B - 7.48 pIC50 33 nM IC50 Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]
ChEMBL In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes B 7.48 pIC50 33 nM IC50 J Med Chem (2000) 43: 1282-1292 [PMID:10753466]
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL Inhibition of CLK mediated SF3B1 activation in human SK-MEL-2 cells assessed as MDM2-pre mRNA exon skipping after 4 hrs by luciferase reporter gene assay relative to control B 4.92 pEC50 12000 nM EC50 Bioorg Med Chem Lett (2017) 27: 406-412 [PMID:28049589]
cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb CDK2 in association with cyclin E - 7.55 pIC50 28 nM IC50 Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]
cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
GtoPdb CDK5 p35 - 7.7 pIC50 20 nM IC50 Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]