Abbott 14c [Ligand Id: 5871] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL212761
  • dihydrofolate reductase/Dihydrofolate reductase in Human [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
Created with Highcharts 10.3.3ValuesChart context menuDihydrofolate reductasepKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • ghrelin receptor/Ghrelin receptor in Human [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
Created with Highcharts 10.3.3ValuesChart context menuGhrelin receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
ChEMBL Inhibition of human recombinant DHFR assessed as rate of depletion of NADPH B 4 pIC50 >100000 nM IC50 J Med Chem (2006) 49: 4459-4469 [PMID:16854051]
ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
GtoPdb - - 8.15 pIC50 7 nM IC50 J Med Chem (2006) 49: 4459-69 [PMID:16854051]
ChEMBL Activity at GHS receptor by calcium flux assay in CHO-K cells F 8.15 pIC50 7 nM IC50 J Med Chem (2006) 49: 4459-4469 [PMID:16854051]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]