RPR121154 [Ligand Id: 580] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL368161
  • C5a1 receptor/C5a anaphylatoxin chemotactic receptor in Human [ChEMBL: CHEMBL2373] [GtoPdb: 32] [UniProtKB: P21730]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
C5a1 receptor/C5a anaphylatoxin chemotactic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2373] [GtoPdb: 32] [UniProtKB: P21730]
ChEMBL Compound was evaluated for the antagonistic activity against C5a anaphylatoxin chemotactic receptor in human neutrophil C5a stimulated respiratory burst assay F 6.1 pIC50 800 nM IC50 Bioorg Med Chem Lett (1997) 7: 907-912
GtoPdb - - 6.1 pIC50 - - - Bioorg Med Chem Lett (1997) 7: 907-912

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]