para-coumaric acid [Ligand Id: 5787] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL66879 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldo-keto reductase family 1 member B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| ChEMBL | Inhibition of human recombinant N-terminus His6-tagged AKR1B1 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spectrometric analysis | B | 4.12 | pIC50 | 76000 | nM | IC50 | Eur J Med Chem (2012) 48: 321-329 [PMID:22236472] |
| ChEMBL | Inhibition of aldose reductase (unknown origin) | B | 6.85 | pIC50 | 140 | nM | IC50 | Med Chem Res (2011) 20: 930-945 |
| Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218] | ||||||||
| ChEMBL | Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spectrometric analysis | B | 4.2 | pIC50 | 63000 | nM | IC50 | Eur J Med Chem (2012) 48: 321-329 [PMID:22236472] |
| Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265] | ||||||||
| ChEMBL | Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry | B | 2.3 | pIC50 | 2.3 | - | logIC50 | Med Chem Res (2012) 21: 3984-3993 |
| calcium/calmodulin-dependent protein kinase II alpha subunit/Calcium/calmodulin-dependent protein kinase type II subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7] | ||||||||
| ChEMBL | Inhibition of [3H]NCS-382 binding to CaMK2alpha (unknown origin) | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (2022) 65: 6656-6676 [PMID:35500061] |
| carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human CA1 by stopped-flow CO2 hydration assay | B | 5.97 | pKi | 1070 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 12/Carbonic anhydrase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human CA12 by stopped-flow CO2 hydration assay | B | 5.1 | pKi | 8010 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| ChEMBL | Inhibition of human catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.1 | pKi | 8010 | nM | Ki | Bioorg Med Chem (2015) 23: 7181-7188 [PMID:26498394] |
| carbonic anhydrase 13/Carbonic anhydrase 13 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse CA13 by stopped-flow CO2 hydration assay | B | 5 | pKi | 10100 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| ChEMBL | Inhibition of mouse carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 5 | pKi | 10100 | nM | Ki | Bioorg Med Chem (2015) 23: 7181-7188 [PMID:26498394] |
| carbonic anhydrase 14/Carbonic anhydrase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human CA14 by stopped-flow CO2 hydration assay | B | 5.18 | pKi | 6680 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| ChEMBL | Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.18 | pKi | 6680 | nM | Ki | Bioorg Med Chem (2015) 23: 7181-7188 [PMID:26498394] |
| carbonic anhydrase 2/Carbonic anhydrase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human CA2 by stopped-flow CO2 hydration assay | B | 6.01 | pKi | 980 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| Carbonic anhydrase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human CA3 by stopped-flow CO2 hydration assay | B | 5.12 | pKi | 7570 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 4/Carbonic anhydrase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human CA4 by stopped-flow CO2 hydration assay | B | 5.02 | pKi | 9600 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 5A/Carbonic anhydrase 5A, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human CA5A by stopped-flow CO2 hydration assay | B | 5.22 | pKi | 5960 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| Carbonic anhydrase 5B, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of human CA5B by stopped-flow CO2 hydration assay | B | 5.11 | pKi | 7760 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| Carbonic anhydrase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human CA6 by stopped-flow CO2 hydration assay | B | 5.17 | pKi | 6720 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 7/Carbonic anhydrase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human CA7 by stopped-flow CO2 hydration assay | B | 5.28 | pKi | 5230 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 9/Carbonic anhydrase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human CA9 by stopped-flow CO2 hydration assay | B | 5.27 | pKi | 5330 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| dipeptidyl peptidase 4/Dipeptidyl peptidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Inhibition of human DPP4 using H-Gly-Pro-AMC peptide substrate assessed as increase in fluorescence for 20 mins by fluorimetric assay | B | 4.08 | pIC50 | 83180 | nM | IC50 | Medchemcomm (2011) 2: 471-477 |
| Estrogen receptor-α/Estrogen receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
| ChEMBL | Agonist activity at human estrogen receptor-alpha by yeast two-hybrid assay in presence of SRC1 | B | 4.79 | pEC50 | 16120 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 3329-3333 [PMID:23608764] |
| Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] | ||||||||
| ChEMBL | Agonist activity at human estrogen receptor-beta by yeast two-hybrid assay in presence of SRC1 | B | 5.31 | pEC50 | 4890 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 3329-3333 [PMID:23608764] |
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
| ChEMBL | Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting | B | 4.85 | pKi | 14000 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 2736-2739 [PMID:21167710] |
| GtoPdb | - | - | 3.51 | pEC50 | 310000 | nM | EC50 | J Lipid Res (2009) 50: 908-14 [PMID:19136666] |
| tyrosinase/Tyrosinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1973] [GtoPdb: 2643] [UniProtKB: P14679] | ||||||||
| ChEMBL | Inhibition of human tyrosinase after 120 mins | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2018) 61: 7395-7418 [PMID:29763564] |
| ChEMBL | Inhibition of tyrosinase in neonatal human epidermal melanocytes | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2020) 63: 13428-13443 [PMID:32787103] |
| ChEMBL | Inhibition of human tyrosinase expressed in HEK293 cells | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2020) 63: 13428-13443 [PMID:32787103] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
