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ChEMBL ligand: CHEMBL499876 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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GPR55/G-protein coupled receptor 55 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6] | ||||||||
ChEMBL | Antagonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as inhibition of lysophosphatidylinositol-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis | F | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188] |
ChEMBL | Agonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis | B | 5 | pEC50 | >10000 | nM | EC50 | ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188] |
GtoPdb | - | - | 5.71 | pEC50 | 1944 | nM | EC50 | Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302] |
GtoPdb | - | - | 8.6 | pEC50 | 2.5 | nM | EC50 | Br J Pharmacol (2007) 152: 825-31 [PMID:17704827] |
ChEMBL | Activation of recombinant human GPR55 expressed in HEK293 cells assessed as increase in [35S]-GTPgammaS stimulation incubated for 60 min by scintillation counting method | F | 8.7 | pEC50 | 2 | nM | EC50 | J Med Chem (2020) 63: 12137-12155 [PMID:32804502] |
GPR18/N-arachidonyl glycine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384898] [GtoPdb: 89] [UniProtKB: Q14330] | ||||||||
ChEMBL | Antagonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as inhibition of THC-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis | F | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188] |
ChEMBL | Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis | B | 5 | pEC50 | >10000 | nM | EC50 | ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188] |
GtoPdb | - | - | 6.08 | pEC50 | 835.7 | nM | EC50 | Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]