tandospirone [Ligand Id: 55] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL274047 (Tandospirona, Tandospirone) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity to Dopamine receptor D2 was determined | B | 6.34 | pKi | 460 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1141-1144 [PMID:11354362] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Binding affinity to Dopamine receptor D4 was determined | B | 8.14 | pKi | 7.2 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1141-1144 [PMID:11354362] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5-hydroxytryptamine 1A receptor was determined | B | 7.49 | pKi | 32 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1141-1144 [PMID:11354362] |
| GtoPdb | - | - | 8.2 | pKi | - | - | - | Eur J Pharmacol (1998) 355: 245-56 [PMID:9760039] |
| ChEMBL | Agonist activity at 5HT1A receptor (unknown origin) | F | 8.24 | pKi | 5.8 | nM | Ki | Eur J Med Chem (2018) 145: 74-85 [PMID:29324345] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue. | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (1988) 31: 1382-1392 [PMID:2898533] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
