ChEMBL ligand: CHEMBL423 (ALO-140102 FREE BASE, Betaxolol, Betoptic, Betoptic susp, Kerledex, Kerlone, SL-7521210 FREE BASE)
β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] β1-adrenoceptor/Beta-1 adrenergic receptor in Rat [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090] Beta-1 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] There should be some charts here, you may need to enable JavaScript!
Beta-2 adrenergic receptor in Bovine [ChEMBL: CHEMBL3373] [UniProtKB: Q28044] Beta-2 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] There should be some charts here, you may need to enable JavaScript!
β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL	Antagonist activity against beta-1 adrenergic receptor (unknown origin)	B	8.8	pKd	1.58	nM	Kd	J. Med. Chem. (2015) 58: 5691-5698 [PMID:25799158]
GtoPdb	-	-	8.8	pKi	-	-	-	Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]
ChEMBL	Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart	B	7.43	pIC50	37.1	nM	IC50	J. Med. Chem. (1982) 25: 931-936 [PMID:6126588]
β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090]
ChEMBL	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	F	6.9	pKd	125.89	nM	Kd	J. Med. Chem. (1987) 30: 1003-1011 [PMID:2884312]
ChEMBL	Antagonist activity at rat beta1 adrenoceptor	B	8.53	pKd	2.95	nM	Kd	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
ChEMBL	Compound was tested for the biological activity at the Beta-1 adrenergic receptor	B	7.4	pKd	39.81	nM	Kd	J. Med. Chem. (1992) 35: 4676-4682 [PMID:1361581]
ChEMBL	In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations	B	8.76	pKd	1.74	nM	Kd	J. Med. Chem. (1983) 26: 950-957 [PMID:6134834]
ChEMBL	In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated guinea pig atria	B	8.76	pKd	1.74	nM	Kd	J. Med. Chem. (1986) 29: 1065-1080 [PMID:2872332]
Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
ChEMBL	Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)	B	7.03	pKd	7.03	-	-Log KD	J. Med. Chem. (1985) 28: 1328-1334 [PMID:2993621]
ChEMBL	Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.	B	6.18	pIC50	657	nM	IC50	J. Med. Chem. (1982) 25: 931-936 [PMID:6126588]
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
ChEMBL	In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tracheal chains contracted with PGF2-alpha	B	6.98	pKd	104.71	nM	Kd	J. Med. Chem. (1983) 26: 950-957 [PMID:6134834]
ChEMBL	In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha contracted guinea pig trachea	B	6.98	pKd	104.71	nM	Kd	J. Med. Chem. (1986) 29: 1065-1080 [PMID:2872332]
β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550]
GtoPdb	-	-	7.2	pKi	-	-	-	Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]