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ChEMBL ligand: CHEMBL493682 (Denopamine, Kalgut, TA 064, TA-064) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.33 | pIC50 | 46900 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
GtoPdb | - | - | 6.1 | pKi | - | - | - |
Mol Pharmacol (1999) 56: 875-85 [PMID:10531390]; J Pharmacol Exp Ther (1993) 267: 785-90 [PMID:7902433]; Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
GtoPdb | - | - | 7.7 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]