sapropterin [Ligand Id: 5276] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201774 (6r-bh4, Dapropterin, Daproterin, R-thbp, Sapropterin, Tetrahydrobiopterin)
  • Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
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  • L-Phenylalanine hydroxylase in Human [GtoPdb: 1240] [UniProtKB: P00439]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL Activity of tetrahydrobiopterin free nNOS B 5.95 pKd 1120 nM Kd Bioorg. Med. Chem. Lett. (2008) 18: 1563-1566 [PMID:18261902]
L-Phenylalanine hydroxylase in Human [GtoPdb: 1240] [UniProtKB: P00439]
GtoPdb Binding affinity for human PAH. - 5.4 pKi 4000 nM Ki J Med Chem (2004) 47: 5962-71 [PMID:15537351]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]